NMDA receptor antagonist MK-801 down-regulates rat striatal proenkephalin and protachykinin mRNAs.

Zhang F; Van Bree L; Albala N; Verslype M; Vanderhaeghen JJ

首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >NMDA receptor antagonist MK-801 down-regulates rat striatal proenkephalin and protachykinin mRNAs.

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NMDA receptor antagonist MK-801 down-regulates rat striatal proenkephalin and protachykinin mRNAs.

机译：NMDA受体拮抗剂MK-801下调大鼠纹状体前脑啡肽和促激肽原mRNA的表达。

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Using quantitative in situ hybridization, a significant decrease in expression of proenkephalin (27.1%) and of protachykinin mRNAs (20.0%) is observed in the rat caudate-putamen 14 days after daily intraperitoneal administration of N-methyl-D-aspartate receptor antagonist MK-801, 2 mg/kg.

机译：使用定量原位杂交，在每天腹膜内施用N-甲基-D-天冬氨酸受体拮抗剂MK后14天，在大鼠尾状丘脑中观察到前脑啡肽（27.1％）和前激肽mRNA（20.0％）的表达明显降低。 -801，2 mg / kg。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |1996年第2期|共4页
作者
Zhang F; Van Bree L; Albala N; Verslype M; Vanderhaeghen JJ;
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正文语种 eng
中图分类基础医学;
关键词
Dizocilpine Maleate; Enkephalins; Excitatory Amino Acid Antagonists; Neostriatum; 地卓西平马来酸盐; 脑啡肽类; 兴奋性氨基酸拮抗剂; 新纹状体; 蛋白质前体; RNA; 信使;

机译：Dizocilpine Maleate;Enkephalins;Excitatory Amino Acid Antagonists;Neostriatum;地卓西平马来酸盐;脑啡肽类;兴奋性氨基酸拮抗剂;新纹状体;蛋白质前体;RNA;信使;

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1. NMDA receptor antagonist MK-801 down-regulates rat striatal proenkephalin and protachykinin mRNAs. [J] . Zhang F, Van Bree L, Albala N, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 1996,第2期

机译：NMDA受体拮抗剂MK-801下调大鼠纹状体前脑啡肽和促激肽原mRNA的表达。
2. Combination therapy of rosiglitazone, a peroxisome proliferator-activated receptor-gamma ligand, and NMDA receptor antagonist (MK-801) on experimental embolic stroke in rats. [J] . Allahtavakoli M, Shabanzadeh A, Roohbakhsh A, Basic & clinical pharmacology & toxicology. . 2007,第5期

机译：罗格列酮，过氧化物酶体增殖物激活的受体-γ配体和NMDA受体拮抗剂（MK-801）联合治疗大鼠栓塞性中风。
3. PAOPA, a potent analogue of Pro-Leu-glycinamide and allosteric modulator of the dopamine D2 receptor, prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: implications for the treatment of negative symptoms in schizophrenia. [J] . Dyck B, Guest K, Sookram C, Schizophrenia research . 2011,第1期

机译：PAOPA是Pro-Leu-甘氨酰胺的强效类似物和多巴胺D2受体的变构调节剂，可预防NMDA受体拮抗剂（MK-801）诱导的大鼠社交互动缺陷：对精神分裂症阴性症状的治疗意义。
4. EFFECTS OF NMDA AND NON-NMDA RECEPTORS ANTAGONISTS ON THE BEHAVIOR OF CULTURED CORTICAL NETWORKS [C] . Laura Bonzano, Marco Bove, Sergio Martinoia Brain Inspired Cognitive Systems . 2004

机译：NMDA和非NMDA受体对拮抗剂对培养皮质网络行为的影响
5. Effect of chronic ethanol exposure on the expression of the N-methyl-D-aspartate (NMDA) receptor 2C subunit and on MK-801 binding sites in the cerebral cortex of the near-term fetal guinea pig. [D] . Chiu, Joanne Wing-Yan. 1997

机译：长期乙醇暴露对近期胎鼠豚鼠大脑皮层N-甲基-D-天冬氨酸（NMDA）受体2C亚单位表达和MK-801结合位点的影响。
6. PAOPA a potent analogue of pro-leu-glycinamide and allosteric modulator of the dopamine D2 receptor prevents NMDA receptor antagonist (MK-801)-induced deficits in social interaction in the rat: Implications for the treatment of negative symptoms in schizophrenia [O] . Bailee Dyck, Kelly Guest, Christal Sookram, -1

机译：paOpa亲-LEU-甘氨酰胺和多巴胺D2受体的变构调节剂的一种有效的类似物预防NmDa受体拮抗剂（mK-801）在社会互动诱导缺陷大鼠：对精神分裂症阴性症状的治疗
7. Combination Therapy of Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-? Ligand, and NMDA Receptor Antagonist (MK-801) on Experimental Embolic Stroke in Rats [O] . Mohammad Allahtavakoli, Alireza Shabanzadeh, Ali Roohbakhsh, 2007

机译：Rosiglitazone的组合治疗，过氧化物酶促增殖物激活的受体 - ？ Ligand和NMDA受体拮抗剂（MK-801）对大鼠实验性栓塞中风
8. NMDA (N-Methyl-D-Aspartate)-Receptor Antagonist, MK-801, Suppresses Limbic Kindling and Kindled Seizures [R] . Gilbert, M. E. 1988

机译：NmDa（N-甲基-D-天冬氨酸） - 受体拮抗剂，mK-801，抑制边缘点燃和点燃癫痫发作

NMDA receptor antagonist MK-801 down-regulates rat striatal proenkephalin and protachykinin mRNAs.

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