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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance.
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8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance.

机译：8-OH-DPAT和MK-801独立于警惕性影响癫痫活动。

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摘要

Vigilance and parallel occurrence of epileptic activity after administration of the 5-HT(1A) agonist 8-OH-DPAT and the NMDA receptor antagonist MK-801 were studied in the genetic absence epilepsy model WAG/Rij rats. Spike-wave discharges (SWD) were present predominantly in passive awake and light slow wave sleep (SWS1) either in control animals or after treatments. Injection of 8-OH-DPAT (20.0 microg/rat i.c.v.) caused marked increase and MK-801 (10.0 microg/rat i.c.v.) decrease in SWD densities, thus the ratios of SWD in passive awake and in SWS1. SWD densities of MK-801 plus 8-OH-DPAT in combination were similar to those of CSF+CSF treated control rats. Both 8-OH-DPAT and MK-801 transiently increased the duration of active awake, increased latency and decreased duration of rapid eye movement (REM) sleep. 8-OH-DPAT increased the amount of SWD despite the decrease in the duration of SWS1. MK-801 decreased the amount of SWD despite the lack of significant change in duration of passive awake or SWS1. Pre-treatment with MK-801 reversed 8-OH-DPAT- induced increase in duration of SWD without any effect on 8-OH-DPAT-induced changes in sleep parameters. Our studies provide evidence that 8-OH-DPAT-induced epileptic activity is independent of its effect on sleep, and that interaction of serotonergic and glutamatergic systems plays a role in the generation of SWD, but not in the regulation of vigilance and sleep.
机译：在基因缺失癫痫模型WAG / Rij大鼠中研究了5-HT（1A）激动剂8-OH-DPAT和NMDA受体拮抗剂MK-801给药后的警惕性和并行发生的癫痫活动。在对照动物或治疗后的被动清醒和轻慢波睡眠（SWS1）中主要存在尖峰波放电（SWD）。注射8-OH-DPAT（20.0微克/大鼠静脉）引起SWD密度显着增加，而MK-801（10.0微克/大鼠静脉）导致SWD密度降低，因此被动清醒和SWS1中SWD的比率。 MK-801加8-OH-DPAT的SWD密度与CSF + CSF处理的对照组大鼠相似。 8-OH-DPAT和MK-801均会短暂增加主动清醒的持续时间，增加等待时间，并减少快速眼动（REM）睡眠的持续时间。尽管SWS1的持续时间减少，但8-OH-DPAT增加了SWD的量。尽管被动清醒或SWS1的持续时间没有显着变化，但MK-801减少了SWD量。用MK-801进行的预处理逆转了8-OH-DPAT诱导的社署病程增加，而对8-OH-DPAT诱导的睡眠参数变化没有任何影响。我们的研究提供了证据，表明8-OH-DPAT诱导的癫痫活动与其对睡眠的影响无关，并且血清素能和谷氨酸能系统的相互作用在SWD的产生中起作用，但在警惕性和睡眠的调节中不起作用。

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