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The complex roles of neurosteroids in depression and anxiety disorders.

机译:神经甾体在抑郁症和焦虑症中的复杂作用。

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摘要

The role of neurosteroids in neuropsychiatric disorders has been thoroughly investigated in many research studies that have stressed their significant pathophysiological function in neuropsychiatry. In this review, we will focus mainly on the steroids active on the GABA(A) receptors studied in anxiety and depression. The aim is to discuss the controversial results reported in research on anxiety and depressive disorders. We suggest the combined use of biological parameters linked to psychopathological dimensions to make more homogeneous diagnoses and to develop more precise therapies for the treatment of depression and anxiety disorders. We discuss the role of neurosteroids in the pathophysiology and therapy of anxiety and depression. Finally, we consider the possibility of using quantification of mRNA expression of steroidogenic enzymes from peripheral sources in neuropsychiatry.
机译:在许多强调神经精神疾病中重要的病理生理功能的研究中,已经对神经类固醇在神经精神疾病中的作用进行了彻底的研究。在这篇综述中,我们将主要关注对焦虑和抑郁症研究的GABA(A)受体具有活性的类固醇。目的是讨论在焦虑和抑郁症研究中报道的有争议的结果。我们建议结合使用与心理病理学维度相关的生物学参数来进行更均一的诊断,并开发出更精确的疗法来治疗抑郁症和焦虑症。我们讨论神经类固醇在焦虑和抑郁的病理生理和治疗中的作用。最后,我们考虑了在神经精神病学中使用量化外周来源类固醇生成酶的mRNA表达的可能性。

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