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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Chronic treatment with a dopamine uptake blocker changes dopamine and acetylcholine but not glutamate and GABA concentrations in prefrontal cortex, striatum and nucleus accumbens of the awake rat.
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Chronic treatment with a dopamine uptake blocker changes dopamine and acetylcholine but not glutamate and GABA concentrations in prefrontal cortex, striatum and nucleus accumbens of the awake rat.

机译：长期用多巴胺摄取阻滞剂治疗可改变清醒大鼠的前额叶皮层，纹状体和伏隔核中的多巴胺和乙酰胆碱，但不会改变谷氨酸和GABA的浓度。

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摘要

The present study was aimed to investigate the effects of a chronic treatment with the dopamine uptake blocker nomifensine on the in vivo extracellular concentrations of dopamine, acetylcholine, glutamate and GABA in the prefrontal cortex, striatum and nucleus accumbens. Male Wistar rats received intraperitoneal (i.p.) daily injections of nomifensine (10 mg/kg) or saline for 22 days. Microdialysis experiments were performed on days 1, 8, 15 and 22 of treatment to evaluate the effects of the injection of nomifensine or saline. Motor activity of the animals was monitored during microdialysis experiments. Injections of nomifensine increased extracellular concentration of dopamine in striatum and nucleus accumbens, but not in prefrontal cortex. Acetylcholine concentrations in striatum but not in nucleus accumbens were increased by nomifensine on days 15 and 22 of treatment. In prefrontal cortex, nomifensine increased acetylcholine levels without differences among days. No changes were found on glutamate and GABA concentrations in the three areas studied. Injections of nomifensine also increased spontaneous motor activity and stereotyped behaviour without differences among days. These results show that systemic chronic treatment with a dopamine uptake blocker produces differential effects on extracellular concentrations of dopamine and acetylcholine, but not glutamate and GABA, in different areas of the brain.
机译：本研究旨在研究长期接受多巴胺摄取阻滞剂诺米芬对前额叶皮层，纹状体和伏隔核中多巴胺，乙酰胆碱，谷氨酸和GABA的体内细胞外浓度的影响。雄性Wistar大鼠每天接受腹膜内（i.p.）注射诺米芬（10 mg / kg）或生理盐水注射22天。在治疗的第1、8、15和22天进行了微透析实验，以评估诺米芬或盐水注射的效果。在微透析实验期间监测动物的运动活动。 Nomifensine注射增加纹状体和伏隔核中多巴胺的细胞外浓度，但不增加额叶前额叶皮层中的浓度。在治疗的第15天和第22天，诺米芬增加了纹状体内而不是伏隔核中的乙酰胆碱浓度。在前额叶皮层，诺美芬增加乙酰胆碱水平，各天之间无差异。在所研究的三个区域中，谷氨酸和GABA浓度均未发现变化。 Nomifensine的注射也增加了自发运动活动和刻板行为，各天之间没有差异。这些结果表明，使用多巴胺摄取阻滞剂的全身性慢性治疗对大脑不同区域的多巴胺和乙酰胆碱的细胞外浓度产生不同的影响，但对谷氨酸和GABA则没有影响。

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