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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Tissue concentration changes of amino acids and biogenic amines in the central nervous system of mice with experimental autoimmune encephalomyelitis (EAE).
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Tissue concentration changes of amino acids and biogenic amines in the central nervous system of mice with experimental autoimmune encephalomyelitis (EAE).

机译：实验性自身免疫性脑脊髓炎（EAE）小鼠中枢神经系统中氨基酸和生物胺的组织浓度变化。

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We have characterized the changes in tissue concentrations of amino acids and biogenic amines in the central nervous system (CNS) of mice with MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE), an animal model commonly used to study multiple sclerosis (MS). High performance liquid chromatography was used to analyse tissue samples from five regions of the CNS at the onset, peak and chronic phase of MOG(35-55) EAE. Our analysis includes the evaluation of several newly examined amino acids including d-serine, and the inter-relations between the intraspinal concentration changes of different amino acids and biogenic amines during EAE. Our results confirm many of the findings from similar studies using different variants of the EAE model as well as those examining changes in amino acid and biogenic amine levels in the cerebrospinal fluid (CSF) of MS patients. However, several notable differences were observed between mice with MOG(35-55)-induced EAE with findings from human studies and other EAE models. In addition, our analysis has identified strong correlations between different amino acids and biogenic amines that appear to change in two distinct groups during EAE. Group I analyte concentrations are increased at EAE onset and peak but then decrease in the chronic phase with a large degree of variability. Group II is composed of amino acids and biogenic amines that change in a progressive manner during EAE. The altered levels of these amino acids and biogenic amines in the disease may represent a critical pathway leading to neurodegenerative processes that are now recognized to occur in EAE and MS.
机译：我们已经表征了MOG（35-55）诱导的实验性自身免疫性脑脊髓炎（EAE）小鼠的中枢神经系统（CNS）氨基酸和生物胺的组织浓度变化，EAE是一种通常用于研究多发性硬化症的动物模型（多发性硬化症）。高效液相色谱法用于分析MOS（35-55）EAE发病，高峰和慢性期中枢神经系统五个区域的组织样本。我们的分析包括对几种新检查的氨基酸（包括d-丝氨酸）进行评估，以及在EAE期间不同氨基酸与生物胺的椎体内浓度变化之间的相互关系。我们的结果证实了使用EAE模型的不同变体进行的相似研究的许多发现，以及那些检查MS患者脑脊液（CSF）中氨基酸和生物胺水平变化的研究结果。但是，在MOG（35-55）诱导的EAE的小鼠之间观察到一些显着差异，这些差异来自人体研究和其他EAE模型。此外，我们的分析还确定了不同的氨基酸与生物胺之间的强相关性，这些氨基酸在EAE期间可能在两个不同的组中发生变化。 I组分析物浓度在EAE发作和峰值时增加，但在慢性期则降低，且变化很大。第II组由氨基酸和生物胺组成，它们在EAE期间会逐渐变化。这些氨基酸和生物胺的水平改变可能代表了导致神经退行性过程的关键途径，现已认识到它在EAE和MS中发生。

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