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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Alteration of serotonin system by polychlorinated biphenyls exposure
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Alteration of serotonin system by polychlorinated biphenyls exposure

机译：多氯联苯暴露改变5-羟色胺系统

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摘要

Although commercial production of polychlorinated biphenyls (PCBs) was banned in 1979, PCBs continue to be an environmental and health concern due to their high bioaccumulation and slow degradation rates. In fact, PCBs are still present in our food supply (fish, meat, and dairy products). In laboratory animals, exposure to single PCB congener or to mixtures of different congeners induces a variety of physiological alterations. PCBs cross the placenta and even exposure at low level is harmful for the foetus by leading to neurodevelopment alterations. Serotonin system which regulates many physiological functions from platelet activation to high cerebral processes and neurodevelopment is one of the targets of PCBs toxicity. The effects of PCBs exposure on serotonin system have been investigated although to a lesser extent compared to its effect in other neurotransmitter systems. This review provides a summary of the results concerning the impact of PCBs exposure (in vitro and in vivo) on serotonin system. Further research is needed to correlate specific deficits with PCB-induced changes in the serotonin system.
机译：尽管多氯联苯（PCB）的商业生产在1979年被禁止，但由于PCBs的高生物蓄积性和缓慢的降解速度，它仍然是环境和健康问题。实际上，PCBs仍然存在于我们的食品供应中（鱼，肉和乳制品）。在实验动物中，暴露于单一PCB同类物或不同同类物的混合物会引起多种生理变化。多氯联苯穿过胎盘，即使低水平的暴露也会导致神经发育改变，从而对胎儿有害。调节从血小板活化到大脑高级过程和神经发育的许多生理功能的5-羟色胺系统是多氯联苯毒性的目标之一。尽管与其他神经递质系统相比，PCBs暴露的影响程度较小，但已经研究了PCBs暴露对5-羟色胺系统的影响。这篇综述总结了有关PCBs暴露（体外和体内）对5-羟色胺系统的影响的结果。需要进一步的研究以将特定缺陷与5-羟色胺系统中PCB诱导的变化相关联。

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