• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >2-Phenylethynyl-butyltellurium improves memory in mice
【24h】

2-Phenylethynyl-butyltellurium improves memory in mice

机译：2-苯基乙炔基丁基碲改善小鼠记忆力

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study was conducted to evaluate the effect of 2-phenylethynyl-butyltellurium (PEBT), an organotellurium compound, at doses of 5 and 10 mg/kg on memory, employing the step-down inhibitory avoidance task in mice. Moreover, the involvement of glutamate uptake and release in cerebral cortex and hippocampus of mice was investigated. A single oral administration (p.o.) of PEBT at the dose of 10 mg/kg 1 h before training (acquisition), immediately after training (consolidation) or 1 h before the test session (retrieval) of the step-down inhibitory avoidance task increased the step-through latency time in comparison to the control mice. In the open-field test, no significant differences in the number of crossings and rearings were observed among groups. The [ 3H]glutamate uptake by cerebral cortex and hippocampal slices of mice was significantly inhibited after 1 h of treatment with PEBT. After 24 h of PEBT exposure, only the hippocampal [ 3H]glutamate uptake was inhibited. The [ 3H]glutamate release by cerebral cortex and hippocampal synaptosomes of mice was not altered. These results suggest that PEBT improved memory stages (acquisition, consolidation and retrieval) in the step-down inhibitory avoidance task in mice. The improvement of memory by PEBT seems most likely to be mediated through an interaction with the amino acid transporters of the glutamatergic system.
机译：进行本研究以评估降压回避规避小鼠的作用，以5和10 mg / kg的剂量评估有机碲化合物2-苯基乙炔基丁基碲（PEBT）对记忆的影响。此外，研究了谷氨酸摄取和释放在小鼠大脑皮质和海马中的参与。在训练（习性）之前，习性（巩固）之后或训练（紧缩）测试前1小时（取回）前1小时以10 mg / kg的剂量单次口服PEBT 10 mg / kg增加与对照组小鼠相比的逐步潜伏时间。在野外试验中，各组之间的杂交和饲养数量没有显着差异。用PEBT处理1小时后，小鼠大脑皮层和海马切片对[3 H]谷氨酸的摄取被显着抑制。 PEBT暴露24小时后，仅抑制海马[3 H]谷氨酸的摄取。小鼠大脑皮层和海马突触体释放的[3 H]谷氨酸没有改变。这些结果表明，PEBT在降低小鼠的抑制性避免任务中改善了记忆阶段（获取，巩固和恢复）。 PEBT对记忆的改善似乎最有可能通过与谷氨酸能系统氨基酸转运蛋白的相互作用来介导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号