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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis.
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Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis.

机译：癫痫患者海马硬化中星形细胞环氧化酶-2的诱导。

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摘要

Induction of cyclooxygenase-2 (COX-2) has been described in a wide range of neurological diseases including animal models of epilepsy. The present study was undertaken to assess COX-2 expression in hippocampal biopsies from patients with therapy-refractive temporal lobe epilepsy (TLE). For this purpose, hippocampal CA1 subfield was dissected from epileptic patients with (n=5) or without (n=2) hippocampal sclerosis (HS). COX-2 expression was investigated using immunohistochemistry and semi-quantitative RT-PCR. COX-2 immunoreactivity in TLE patient material in the absence of HS was restricted to a few neurons of the hippocampus. In the presence of HS, on the other hand, a significant induction of astrocytic COX-2 immunoreactivity associated with a concomitant increase in the steady-state level of COX-2 mRNA was observed in the CA1 subfield. These findings suggest that induction of astrocytic COX-2 is implicated in the pathogenesis of HS in TLE and is consistent with the previous findings of increased concentrations of prostaglandins in the cerebrospinal fluid of these patients.
机译：已经在包括癫痫动物模型在内的多种神经系统疾病中描述了环氧合酶2（COX-2）的诱导。本研究旨在评估COX-2在难治性颞叶癫痫（TLE）患者海马活检组织中的表达。为此，从患有（n = 5）或没有（n = 2）海马硬化（HS）的癫痫患者中解剖海马CA1子区。使用免疫组织化学和半定量RT-PCR研究COX-2的表达。在没有HS的情况下，TLE患者材料中的COX-2免疫反应仅限于海马的少数神经元。另一方面，在HS的存在下，在CA1子域中观察到了与星形胶质细胞COX-2免疫反应性的显着诱导，其伴随着COX-2 mRNA稳态水平的升高。这些发现提示星形细胞COX-2的诱导与TLE中HS的发病机制有关，并且与先前发现这些患者脑脊液中前列腺素浓度升高的发现一致。

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