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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Cyclic AMP and sympathetic neuronal programmed cell death.
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Cyclic AMP and sympathetic neuronal programmed cell death.

机译：循环AMP和交感神经元程序性细胞死亡。

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摘要

The survival and proper functioning of sympathetic neurons are dependent on nerve growth factor (NGF). When immature sympathetic neurons are deprived of NGF, they undergo an 'active' dying process usually termed 'programmed cell death' or 'apoptosis'. This trophic factor dependence is age-related such that the cells become less dependent on NGF as they mature. Removal of NGF in immature cultures, which triggered the process of programmed cell death, resulted in a significant decrease of intracellular cAMP levels. In contrast, when these cells matured in culture and became relatively NGF independent, NGF withdrawal did not lead to a drop of cAMP levels. Pituitary adenylate cyclase-activating polypeptide (PACAP), a naturally occurring bioactive peptide structurally similar to VIP, could increase cAMP levels in these sympathetic neurons, and delay neuronal cell death resulting from NGF deprivation. These results suggest that PACAP may serve as a neurotrophic factor in sympathetic neurons.
机译：交感神经元的存活和正常功能取决于神经生长因子（NGF）。当未成熟的交感神经元被剥夺NGF时，它们会经历“活跃的”死亡过程，通常被称为“程序性细胞死亡”或“凋亡”。这种营养因子依赖性与年龄有关，因此随着细胞的成熟，它们对NGF的依赖性降低。未成熟培养物中NGF的去除会触发程序性细胞死亡过程，从而导致细胞内cAMP水平显着下降。相反，当这些细胞在培养物中成熟并变得相对独立于NGF时，NGF的撤回不会导致cAMP水平的下降。垂体腺苷酸环化酶激活多肽（PACAP）是一种天然存在的生物活性肽，在结构上类似于VIP，可以增加这些交感神经元中的cAMP水平，并延迟NGF剥夺导致神经元细胞死亡。这些结果表明PACAP可能是交感神经元的神经营养因子。

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