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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Increase in hippocampal cell death after treatment with kainate in zinc deficiency.
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Increase in hippocampal cell death after treatment with kainate in zinc deficiency.

机译：红藻氨酸锌缺乏症治疗后海马细胞死亡的增加。

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摘要

Susceptibility to kainate-induced seizures is enhanced by zinc deficiency. To evaluate kainate-induced excitotoxicity in zinc deficiency, the relationship between kainate-induced seizures and hippocampal cell death was examined in control and zinc-deficient mice. Mice were fed a control and zinc-deficient diet for 4 weeks, and then intraperitoneally injected with 12 mg/kg kainate every 60 min three times. The rate of dead mice to the total mice was higher in zinc-deficient group than in control group 3 days after the last injection of kainate. In the survivals, which exhibited tonic convulsions in both control and zinc-deficient groups, kainate-induced hippocampal cell death was also analyzed by cresyl violet staining. Neuronal loss was more observed in the CA1, CA2 and CA3 pyramidal cell layers of zinc-deficient group than those of the control group. TUNEL-positive cells were significantly more detected in the CA1 and CA3 pyramidal cell layers of zinc-deficient group. These results demonstrate that kainate-induced hippocampal cell death occurs more easily in zinc deficiency. Extracellular zinc concentration detected with ZnAF-2 was significantly decreased in the hippocampal CA3 of zinc-deficient mice, in agreement with the previous data measured by in vivo microdialsysis. Synaptically released zinc may be less involved in kainate-induced hippocampal cell death in zinc deficiency.
机译：锌缺乏会增强海藻酸盐诱发的癫痫发作的敏感性。为了评估在缺乏锌的情况下海藻酸盐引起的兴奋性毒性，在对照组和缺锌小鼠中检查了海藻酸盐引起的癫痫发作与海马细胞死亡之间的关系。给小鼠喂食对照和缺锌饮食4周，然后每60分钟腹膜内注射12mg / kg的海藻酸盐3次。最后一次注射海藻酸盐后3天，锌缺乏组的死亡小鼠占总小鼠的比率高于对照组。在对照组和缺锌组均表现为强直性抽搐的存活中，还通过甲酚紫染色分析了海藻酸盐诱导的海马细胞死亡。缺锌组的CA1，CA2和CA3锥体细胞层比对照组的神经元丢失更多。在缺锌组的CA1和CA3锥体细胞层中检测到的TUNEL阳性细胞明显更多。这些结果表明，在锌缺乏症下，海藻酸盐诱导的海马细胞死亡更容易发生。锌缺乏症小鼠海马CA3中用ZnAF-2检测到的细胞外锌浓度显着降低，这与先前通过体内微透析测量的数据一致。突触释放的锌可能与锌缺乏引起的海藻酸盐诱导的海马细胞死亡较少相关。

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