• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes.
【24h】

Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes.

机译：第一组代谢型谷氨酸受体通过雷帕霉素的哺乳动物靶标（mTOR）和大鼠纹状体和海马突触小体中的细胞外信号调节激酶（ERK 1/2）信号通路激活p70S6激酶。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Group I metabotropic glutamate receptors (mGluRs) have been demonstrated to play a role in synaptic plasticity via a rapamycin-sensitive mRNA translation signaling pathway. Various growth factors can stimulate this pathway, leading to the phosphorylation and activation of mammalian target of rapamycin (mTOR), a serine/threonine protein kinase that modulates the activity of several translation regulatory factors, such as p70S6 kinase. However, little is known about the cellular and molecular mechanisms that bring the plastic changes of synaptic transmission after stimulation of group I mGluRs. Here, we investigated the role of the mTOR-p70S6K and the ERK1/2-p70S6K pathways in rat striatal and hippocampal synaptoneurosomes after group I mGluR stimulation. Our findings show that (S)-3,5-dihydroxyphenylglycine (DHPG) increases significantly the activation of mTOR and p70S6K (Thr389, controlled by mTOR) in both brain areas. The mTOR activation is dose-dependent and requires the stimulation of mGluR1 subtypereceptors as for the p70S6K activation observed in striatum and hippocampus. In addition, the p70S6K (Thr421/Ser424) activation via the ERK1/2 activation is increased and involved also mGluR1 receptors. These results demonstrate that group I mGluRs are coupled to mTOR-p70S6K and ERK1/2-p70S6K pathways in striatal and hippocampal synaptoneurosomes. The translational factor p70S6K could be involved in the group I mGluRs-modulated synaptic efficacy.
机译：已证实I组代谢型谷氨酸受体（mGluRs）通过雷帕霉素敏感的mRNA翻译信号传导途径在突触可塑性中发挥作用。多种生长因子可刺激该途径，导致雷帕霉素（mTOR）哺乳动物靶标的磷酸化和激活，雷帕霉素是一种丝氨酸/苏氨酸蛋白激酶，可调节几种翻译调节因子（例如p70S6激酶）的活性。然而，关于刺激I类mGluR后引起突触传递的塑性变化的细胞和分子机制知之甚少。在这里，我们调查了mTORI刺激后，mTOR-p70S6K和ERK1 / 2-p70S6K途径在大鼠纹状体和海马突触小体中的作用。我们的研究结果表明（S）-3,5-二羟基苯基甘氨酸（DHPG）在两个大脑区域均显着增加了mTOR和p70S6K（Thr389，由mTOR控制）的激活。正如在纹状体和海马中观察到的p70S6K激活一样，mTOR激活是剂量依赖性的，需要刺激mGluR1亚型受体。此外，通过ERK1 / 2激活的p70S6K（Thr421 / Ser424）激活增加，并且还涉及mGluR1受体。这些结果表明，第I组mGluRs与纹状体和海马突触神经小体中的mTOR-p70S6K和ERK1 / 2-p70S6K途径偶联。翻译因子p70S6K可能参与了第一类mGluRs调节的突触功效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号