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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats.
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Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating phosphatidylinositol 3-kinase signaling in the hippocampus of induced aging rats.

机译：强制中等强度的跑步机运动通过增加NGF的水平并刺激衰老大鼠海马中的磷脂酰肌醇3激酶信号传导来抑制细胞凋亡。

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摘要

While nerve growth factor (NGF) activates various signaling cascades, the phosphatidylinositol 3-kinase (PI3-K)/Akt pathway plays a pivotal role in controlling the survival of neurons, although this activity declines during the aging process. We investigated the effect of forced moderate-intensity treadmill exercise on the level of NGF and the PI3-K/Akt signaling pathway in the hippocampus of induced aging rats. Forty-five male Sprague-Dawley rats were divided into the following three groups: (1) control group, in which aging was not induced (CON: n=15), (2) aging-control group, in which aging was induced but the rats were not subjected to exercise (ACON: n=15), and (3) the aging-exercise group, in which aging was induced and the rats were subjected to treadmill exercise (AEX: n=15). d-Galactose (50mg/kg) was injected into the abdominal cavity for 8 weeks to induce aging. Rats were subjected to treadmill exercise 5 days a week for 8 weeks, and the speed of the treadmill was gradually increased. The protein levels of NGF, P-PI3-K, and P-Akt were significantly high in the AEX group (p<0.01, p<0.01, and p<0.001, respectively). Tyrosine kinase A (Trk A) receptor level was significantly higher in the CON and AEX groups than in the ACON group (p<0.01). TUNEL assay showed a significant reduction in apoptosis in the AEX group (p<0.001). Caspase-3 activation was significantly decreased in the AEX and CON groups (p<0.05). These results show that forced moderate-intensity treadmill exercise increases the level of NGF and activates P-PI3-K to induce P-Akt in order to suppress apoptotic cell death in the hippocampus of induced aging rats.
机译：尽管神经生长因子（NGF）激活各种信号级联，但磷脂酰肌醇3-激酶（PI3-K）/ Akt途径在控制神经元的存活中起着关键作用，尽管该活性在衰老过程中会下降。我们调查了强迫中等强度的跑步机运动对诱导衰老大鼠海马中NGF和PI3-K / Akt信号通路水平的影响。将45只雄性Sprague-Dawley大鼠分为以下三组：（1）对照组，其中未诱导衰老（CON：n = 15），（2）衰老对照组，其中诱导衰老，但衰老。大鼠不进行运动（ACON：n ＝ 15），和（3）衰老运动组，其中诱导衰老并且大鼠进行跑步机运动（AEX：n ＝ 15）。将d-半乳糖（50mg / kg）注射入腹腔8周以诱发衰老。大鼠每周5天在跑步机上锻炼8周，跑步机的速度逐渐提高。在AEX组中，NGF，P-PI3-K和P-Akt的蛋白质水平显着较高（分别为p <0.01，p <0.01和p <0.001）。 CON和AEX组的酪氨酸激酶A（Trk A）受体水平明显高于ACON组（p <0.01）。 TUNEL分析显示，AEX组的凋亡明显减少（p <0.001）。在AEX和CON组中，Caspase-3的激活显着降低（p <0.05）。这些结果表明，强制中等强度的跑步机运动可增加NGF的水平并激活P-PI3-K诱导P-Akt，从而抑制衰老大鼠海马中的凋亡细胞死亡。

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