...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >The role of biodegradable engineered scaffolds seeded with Schwann cells for spinal cord regeneration.
【24h】

The role of biodegradable engineered scaffolds seeded with Schwann cells for spinal cord regeneration.

机译：植入施万旺细胞的可生物降解工程支架在脊髓再生中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Spinal cord injury is very complicated, as there are factors in the body that inhibit its repair. Although regeneration of the mammalian central nervous system (CNS) was once thought to be impossible, studies over the past two decades have shown that axonal growth after spinal cord injury can occur when provided with the correct substratum. Traditionally, tissue transplantation or peripheral nerve grafting are used to repair damaged or diseased regions of the CNS, but donor shortage and immunological problems associated with infectious disease are often encountered. Fortunately, recent advances in neuroscience, cell culture, and biomaterials provide optimistic future using new treatments for nerve injuries. Biomaterial scaffold creates substrate within which cells are instructed to form a tissue or an organ in a highly controlled way. The principal function of a scaffold is to direct cell behavior such as migration, proliferation, differentiation, maintenance of phenotype, and apoptosis by facilitatingsensing and responding to the environment via cell-matrix and cell-cell communications. Therefore, having such abilities provides scaffolds seeded with a special type of cell as an important part of tissue engineering and regenerative medicine which spinal cord regeneration is an example of. Nevertheless, the vast number of biodegradable synthetic and natural biopolymers makes choosing the right one very difficult. In this review article, it was tried to provide an inclusive survey of biopolymers seeded with Schwann cells (SCs) to be used for axonal regeneration in the nervous system.
机译：脊髓损伤非常复杂，因为体内有某些因素会抑制其修复。尽管曾经认为哺乳动物中枢神经系统（CNS）的再生是不可能的，但过去二十年的研究表明，提供正确的基质后，脊髓损伤后的轴突生长会发生。传统上，组织移植或周围神经移植用于修复中枢神经系统的受损或患病区域，但是捐赠者短缺和与传染病相关的免疫学问题经常遇到。幸运的是，神经科学，细胞培养和生物材料方面的最新进展为使用神经损伤的新疗法提供了广阔的前景。生物材料支架创造了一种底物，其中细胞被指示以高度受控的方式形成组织或器官。支架的主要功能是通过促进细胞基质和细胞间通讯对环境的反应，从而指导细胞行为，例如迁移，增殖，分化，表型维持和凋亡。因此，具有这样的能力提供了种有特殊类型细胞的支架，作为组织工程和再生医学的重要部分，脊髓再生就是其中的一个例子。然而，大量可生物降解的合成和天然生物聚合物使选择正确的生物聚合物非常困难。在这篇综述文章中，试图对包含施万细胞（SC）的生物聚合物进行神经包容性调查，以用于神经系统的轴突再生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号