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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >The vesicular monoamine transporter: from chromaffin granule to brain.
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The vesicular monoamine transporter: from chromaffin granule to brain.

机译：囊泡单胺转运蛋白：从嗜铬粒蛋白颗粒到大脑。

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摘要

All characterized monoaminergic cells utilize the same transport system for the vesicular accumulation of monoamines prior to their release. This system operates in neuronal (catecholaminergic, serotoninergic or histaminergic) as well as in endocrine or neuroendocrine cells. For several decades, chromaffin granules from bovine adrenal medulla have been used as a model system, allowing progress in the understanding of the biophysics, the biochemistry and the pharmacology of the monoamine vesicular transporter. The transporters from rat, bovine and man have been cloned. Surprisingly, two genes encode different isoforms of the protein which are differentially expressed in monoaminergic systems. The conjunction of recombinant DNA techniques and expression in secretory or non-secretory cells with the large body of data obtained on the chromaffin granule transporter has allowed rapid progress in the study of the protein. But interestingly enough, this progress has open new possibilities in the study of biological problems, especially in the brain. The transporter is useful for the determination of the relationship between small and large dense core vesicles, for the understanding of the mechanism of the drugs such as 1-methyl-4-phenylpyridinium (MPP+), tetrabenazine or amphetamines, and as a marker in brain development. The possibility of regulations at the vesicular transporter level and of their effect on the quantum size has to be investigated. The vesicular monoamine transporter is also an important target for brain imaging.
机译：所有特征化的单胺能细胞在释放前都利用相同的转运系统进行单胺的囊泡积累。该系统在神经元（儿茶酚胺能，5-羟色胺能或组胺能）以及内分泌或神经内分泌细胞中起作用。几十年来，来自牛肾上腺髓质的嗜铬粒蛋白颗粒已被用作模型系统，从而使人们对单胺囊泡转运蛋白的生物物理学，生物化学和药理学的理解有了进步。从大鼠，牛和人的转运蛋白已被克隆。令人惊讶地，两个基因编码蛋白质的不同同工型，其在单胺能系统中差异表达。重组DNA技术的结合以及在分泌或非分泌细胞中的表达与通过嗜铬粒细胞颗粒转运蛋白获得的大量数据相结合，已经使蛋白质的研究迅速发展。但有趣的是，这一进展为生物学问题（尤其是大脑）的研究开辟了新的可能性。该转运蛋白可用于确定大而密的核心囊泡之间的关系，有助于理解1-甲基-4-苯基吡啶鎓（MPP +），丁苯那嗪或苯丙胺等药物的作用机理，并可作为脑中的标志物发展。必须研究水泡转运蛋白水平调控的可能性及其对量子尺寸的影响。囊泡单胺转运蛋白也是脑成像的重要目标。

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