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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >The electrotonic architecture of the retinal microvasculature: Diabetes-induced alteration
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The electrotonic architecture of the retinal microvasculature: Diabetes-induced alteration

机译：视网膜微血管的电渗结构：糖尿病引起的改变

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Although microvascular cell death is a well established hallmark of diabetic retinopathy, which is a major cause of vision loss, much remains to be learned about the functional changes that precede the onset of morphological damage to retinal blood vessels. Early alterations of function are of interest since they may contribute to the development of irreversible pathological events. Because one of the earliest retinal effects of diabetes is the dysregulation of blood flow, we asked whether diabetes alters the functional organization of the capillary/arteriolar complex, which is the operational unit that plays an important role in regulating local perfusion. In this study, the effect of diabetes on the electrotonic architecture of the retinal microvasculature was characterized. To do this, we quantified the efficacy by which voltages are transmitted between pairs perforated-patch pipettes sealed onto abluminal cells located at well defined locations in capillary/arteriolar complexes freshly isolated from the retinas of rats made diabetic by streptozotocin. Results of these dual recording experiments were compared with data from similar experiments performed on non-diabetic retinal microvessels. These experiments revealed that diabetes caused a ～5-fold increase in the rate at which a voltage decays as it axially spreads through the retinal microvasculature. In contrast, the efficacy of radial abluminal cell/endothelial cell transmission was not significantly affected by diabetes. Based on the results of this study, which is the first to characterize how diabetes affects voltage transmission in capillary/arteriolar complexes of any tissue, we concluded that by selectively inhibiting axial transmission, diabetes alters the electrotonic architecture of the retinal microvasculature. This diabetes-induced alteration in the functional organization of the capillary/arteriolar unit is likely to impair its ability to efficiently and effectively regulate blood flow and thereby, may contribute to the progression of sight-threatening complications of diabetic retinopathy.
机译：尽管微血管细胞死亡是糖尿病性视网膜病的公认标志，糖尿病性视网膜病是视力丧失的主要原因，但是关于视网膜血管形态学损害发生之前的功能变化，仍有许多知识有待研究。早期的功能改变是令人感兴趣的，因为它们可能有助于不可逆的病理事件的发展。由于糖尿病最早的视网膜作用之一是血流调节异常，因此我们询问糖尿病是否会改变毛细血管/小动脉复合体的功能组织，而毛细血管/小动脉复合体是在调节局部灌注中起重要作用的操作单位。在这项研究中，表征了糖尿病对视网膜微血管的电渗结构的影响。为此，我们量化了在一对刚从从链脲佐菌素制成的糖尿病大鼠视网膜中分离的毛细血管/小动脉复合体中定义明确的位置处的房室细胞上密封的成对穿孔膜移液管之间传输电压的功效。将这些双重记录实验的结果与在非糖尿病性视网膜微血管上进行的类似实验的数据进行比较。这些实验表明，糖尿病引起的电压沿轴向通过视网膜微脉管系统扩散的速率降低了约5倍。相反，糖尿病未显着影响radial骨腹腔/内皮细胞传输的功效。基于这项研究的结果，这是第一个表征糖尿病如何影响任何组织的毛细血管/小动脉复合体中电压传递的特征的研究，我们得出结论，通过选择性抑制轴向传递，糖尿病可以改变视网膜微脉管系统的电声结构。糖尿病引起的毛细血管/小动脉单元功能组织的改变可能会削弱其有效和有效地调节血流的能力，从而可能导致威胁视力的糖尿病性视网膜病并发症的发展。

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