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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the dorsal raphe nucleus to 5-HT1A receptor stimulation in the rat
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Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the dorsal raphe nucleus to 5-HT1A receptor stimulation in the rat

机译：纹状体纹状体通路的单侧病变可降低大鼠背核中GABA中间神经元对大鼠5-HT1A受体刺激的反应

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摘要

This study examined the firing rate and pattern of electrophysiologically and chemically identified GABA interneurons in the dorsal raphe nucleus (DRN), and role of 5-HT1A receptor agonist 8-OH-DPAT and the medial prefrontal cortex (mPFC) in the firing activity in rats with 6-hydroxydopamine lesions of the substantia nigra pars compacta (SNc). The interneurons in rats with lesions of the SNc showed a more burst-firing, while having no change in the firing rate; the mPFC and combined mPFC and SNc lesions in rats decreased the firing rate of the interneurons and firing pattern shifted towards a more burst-firing compared to rats with sham lesions of the SNc, respectively. In rats with sham lesions of the SNc, administration of 8-OH-DPAT (1-243 μg/kg, i.v.) produced excitatory-inhibitory, excitatory and inhibitory effects in the firing rate of individual interneurons. However, when these effects were averaged over the group, 8-OH-DPAT had no significant effect on firing rate. In rats with lesions of the SNc, mPFC and the paired lesions, 8-OH-DPAT, at the same doses, inhibited all interneurons tested, respectively. Cumulative doses producing inhibition in rats with the paired lesions were higher than that of rats with lesions of the mPFC. In contrast to rats with sham lesions of the SNc, SNc lesion reduced expression of 5-HT1A receptor on parvalbumin positive neurons in the DRN, a subpopulation of GABA interneurons. Our results indicate that the SNc and mPFC regulate the firing activity of GABA interneurons in the DRN. Furthermore, response of likely GABA interneurons to systemic administration of 8-OH-DPAT is altered by lesion of the SNc and mPFC.
机译：这项研究检查了背缝核（DRN）中电生理和化学鉴定的GABA中间神经的激发速率和模式，以及5-HT1A受体激动剂8-OH-DPAT和内侧前额叶皮层（mPFC）在激发中的作用大鼠黑质致密部（SNc）的6-羟基多巴胺损伤。 SNc损伤大鼠中的神经元表现出更强的爆发性，而发动率没有变化。与具有SNc假性病变的大鼠相比，大鼠中的mPFC以及合并的mPFC和SNc病变降低了中神经元的放电速率，并且放电模式朝着更强的脉冲发射方向转移。在患有SNc假性损伤的大鼠中，施用8-OH-DPAT（1-243μg/ kg，静脉内）对单个中间神经元的放电速率产生兴奋性抑制，兴奋性和抑制性作用。但是，当将这些效果在整个组中平均时，8-OH-DPAT对射击速率没有显着影响。在患有SNc损伤的大鼠中，mPFC和配对损伤的8-OH-DPAT剂量相同，分别抑制了所有测试的神经元。在成对病变的大鼠中产生抑制作用的累积剂量要高于在mPFC病变中的大鼠。与具有SNc假性损伤的大鼠相反，SNc损伤减少了DRN（GABA中神经元的一个亚群）中小白蛋白阳性神经元上5-HT1A受体的表达。我们的结果表明，SNc和mPFC调节DRN中GABA interneurons的激发活性。此外，SNc和mPFC的病变改变了可能的GABA中神经元对全身给药8-OH-DPAT的反应。

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