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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Exposure to novel environment is characterized by an interaction of D1/NMDA receptors underlined by phosphorylation of the NMDA and AMPA receptor subunits and activation of ERK1/2 signaling, leading to epigenetic changes and gene expression in rat hippocampus
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Exposure to novel environment is characterized by an interaction of D1/NMDA receptors underlined by phosphorylation of the NMDA and AMPA receptor subunits and activation of ERK1/2 signaling, leading to epigenetic changes and gene expression in rat hippocampus

机译：暴露于新型环境的特征是D1 / NMDA受体之间的相互作用，其下端为NMDA和AMPA受体亚基的磷酸化以及ERK1 / 2信号的激活，从而导致大鼠海马的表观遗传变化和基因表达

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Interactions between dopamine and glutamate receptors are essential for prefrontal cortical (PFC) and hippocampal cognitive functions. The hippocampus has been identified as a detector of a novel stimulus, where an association between incoming information and stored memories takes place. Further to our previous results which showed a strong synergistic interaction of dopamine D1 and glutamate NMDA receptors, the present study is going to investigate the functional status of that interaction in rats, following their exposure to a novel environment. Our results showed that the "spatial" novelty induced in rat hippocampus and PFC (a) a significant increase in phosphorylation of NMDA and AMPA receptor subunits, as well as a robust phosphorylation/ activation of ERK1/2 signaling, which are both dependent on the concomitant stimulation of D1/NMDA receptors and are both abolished by habituation procedure, (b) chromatin remodeling events (phosphorylation-acetylation of histone H3) and (c) an increase in the immediate early genes (IEGs) c-Fos and zif-268 expression in the CA1 region of hippocampus, which is dependent on the co-activation of D1/NMDA and acetylcholine muscarinic receptors. In conclusion, our results clearly show that a strong synergistic interaction of D1/NMDA receptor is required for the novelty-induced phosphorylation of NMDA and AMPA receptor subunits and for the robust activation of ERK1/2 signaling, leading to chromatin remodeling events and the expression of the IEGs c-Fos and zif-268, which are involved in the regulation of synaptic plasticity and memory consolidation.
机译：多巴胺和谷氨酸受体之间的相互作用对于额叶前皮质（PFC）和海马认知功能至关重要。海马已被识别为一种新型刺激的检测器，在这种刺激中，输入信息与存储的记忆之间发生关联。除了我们先前的结果显示多巴胺D1和谷氨酸NMDA受体之间存在强的协同相互作用外，本研究还将研究大鼠在暴露于新环境后这种相互作用的功能状态。我们的研究结果表明，在大鼠海马和PFC中诱导的“空间”新颖性（a）NMDA和AMPA受体亚基的磷酸化显着增加，以及ERK1 / 2信号转导的强大磷酸化/激活，这两者都依赖于D1 / NMDA受体的伴随刺激，并且都被习惯化过程所废除，（b）染色质重塑事件（组蛋白H3的磷酸化-乙酰化）和（c）立即早期基因（IEG）c-Fos和zif-268的增加表达在海马CA1区，这取决于D1 / NMDA和乙酰胆碱毒蕈碱受体的共激活。总之，我们的结果清楚地表明，新颖诱导的NMDA和AMPA受体亚基的磷酸化以及ERK1 / 2信号的强烈激活需要D1 / NMDA受体的强协同相互作用，从而导致染色质重塑事件和表达。 IEG c-Fos和zif-268，它们参与突触可塑性和记忆整合的调节。

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