...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Neuroprotective and anticonvulsant effects of organic and conventional purple grape juices on seizures in Wistar rats induced by pentylenetetrazole
【24h】

Neuroprotective and anticonvulsant effects of organic and conventional purple grape juices on seizures in Wistar rats induced by pentylenetetrazole

机译：有机和常规紫葡萄汁对戊四唑诱发的Wistar大鼠癫痫发作的神经保护和抗惊厥作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Epilepsy is the most common neurological disorder worldwide. Studies have shown that recurrent seizures may increase the concentration of reactive oxygen species, which can lead to oxidative stress and neuronal damage. These seizures result in substantial deleterious effects on an individual's health. Organic and conventional grape juices are rich in polyphenols, compounds with important antioxidant activity. However, these juices could have differences in their polyphenol content. The aim of this study was to investigate the neuroprotective and anticonvulsant effects of organic and conventional grape juice treatments in Wistar rats against pentylenetetrazole (a convulsant drug)-induced damage. In addition, we evaluated potential behavioral changes in rats treated with the juices and the polyphenolic profile of those samples. Animals (n = 16 in each group) received treatment with saline, organic or conventional grape juice for 17 days. On the eighteenth day, behavioral changes were evaluated by an open field test. Afterwards, half of the rats from each group received pentylenetetrazole and were observed for 30 min to evaluate possible seizure characteristics. The animals were subsequently killed by decapitation and their hippocampus, cerebellum and cerebral cortex tissues were isolated. The results of this study showed that neither organic nor conventional grape juice altered the behavior parameters, and no statistical differences were observed in the seizure characteristics of the groups. Nevertheless, both juice types were able to protect from lipid and protein oxidative damage, decrease nitric oxide content and increase enzymatic (superoxide dismutase and catalase) and non-enzymatic (sulfhydryl protein) antioxidant defenses in brain tissues following pentylenetetrazole-induced seizures. In general, organic juice showed superior results in each test, probably due to its higher polyphenol content relative to conventional juice. These results indicate that grape juices can provide further insight into natural neuroprotective compounds and may lead to the development of new therapeutic strategies for epileptic patients.
机译：癫痫病是全世界最常见的神经系统疾病。研究表明，反复发作可能会增加活性氧的浓度，从而导致氧化应激和神经元损伤。这些癫痫发作对个人的健康造成严重的有害影响。有机和常规葡萄汁富含多酚，这些化合物具有重要的抗氧化活性。但是，这些果汁的多酚含量可能有所不同。这项研究的目的是研究有机和常规葡萄汁处理在Wistar大鼠中对戊烯四唑（一种惊厥药）引起的损伤的神经保护和抗惊厥作用。此外，我们评估了用果汁和这些样品的多酚谱处理的大鼠的潜在行为变化。动物（每组n = 16）接受盐水，有机或常规葡萄汁处理17天。在第十八天，通过露天试验评估行为改变。之后，每组一半的大鼠接受戊四氮，并观察30分钟以评估可能的癫痫发作特征。随后将动物断头处死，并分离其海马，小脑和大脑皮层组织。这项研究的结果表明，有机葡萄汁和常规葡萄汁都没有改变行为参数，并且两组的癫痫发作特征均未观察到统计学差异。然而，两种类型的果汁都能够保护脂质和蛋白质免受氧化损伤，减少一氧化氮的含量，并增加戊四唑诱发癫痫发作后脑组织中的酶促（超氧化物歧化酶和过氧化氢酶）和非酶促（巯基蛋白）的抗氧化防御能力。通常，有机果汁在每个测试中均显示出优异的结果，这可能是由于其有机酚相对于传统果汁的含量较高。这些结果表明葡萄汁可以提供对天然神经保护化合物的进一步了解，并可能导致癫痫患者新的治疗策略的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号