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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Motor behavior correlates with striatal [18F]-DOPA uptake in MPTP-lesioned primates
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Motor behavior correlates with striatal [18F]-DOPA uptake in MPTP-lesioned primates

机译：运动行为与MPTP病变灵长类动物纹状体[18F] -DOPA摄取相关

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The MPTP-lesioned monkey is considered as the best animal model for Parkinson's disease (PD). It has damage to dopaminergic cell groups and motor dysfunction similar to that seen in PD. Correlations between these two parameters have been described but there is a lack of formal statistical analyses on dopaminergic function as assessed by [18F]-F-DOPA PET and objectively rated motor behavior in longitudinal experiments. Eight rhesus monkeys received two MPTP infusions: first in one carotid artery, and after eight weeks in the other. Motor behavior and [18F]-F-DOPA uptake were measured at three stages: baseline, unilateral and bilateral. We correlated movement with radiotracer uptake across these three stages. MPTP caused the expected parkinsonian motor signs which were accompanied by lower radioactivity concentrations in the striatum. There were significant correlations between dopaminergic function and behavior. In conclusion, striatal [ 18F]-F-DOPA uptake correlates inversely with the severity of motor impairment in MPTP-lesioned non-human primates. Both behavioral scoring and [18F]-F-DOPA PET scans are useful and sensitive methods to monitor dopaminergic degeneration within subjects.
机译：MPTP损伤的猴子被认为是帕金森氏病（PD）的最佳动物模型。与PD相似，它对多巴胺能细胞群有损害，运动功能障碍。已经描述了这两个参数之间的相关性，但缺乏通过[18F] -F-DOPA PET评估的多巴胺能功能和在纵向实验中客观评估的运动行为的正式统计分析。八只恒河猴接受了两次MPTP输注：首先是在一条颈动脉中输注，然后是在另一周中输注八周。在三个阶段测量运动行为和[18F] -F-DOPA摄取：基线，单侧和双侧。我们将这三个阶段的运动与放射性示踪剂的吸收相关联。 MPTP引起了预期的帕金森氏运动征，并伴有纹状体中放射性浓度降低。多巴胺能功能与行为之间存在显着相关性。总之，纹状体[18 F] -F-DOPA摄取与MPTP损伤的非人类灵长类动物运动障碍的严重程度成反比。行为评分和[18F] -F-DOPA PET扫描都是监测受试者体内多巴胺能变性的有用且敏感的方法。

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