• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type
【24h】

Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

机译：儿茶素水合物改善链脲佐菌素诱发的阿尔茨海默氏型痴呆大鼠模型的认知障碍和神经变性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive decline and enhancement of oxidative loads in the brain. Flavonoids have been considered to exert human health benefits by anti-oxidant and anti-inflammatory properties. The present study is aimed to elucidate the neuroprotective effect of catechin hydrate (CH), a natural flavanoid with potential antioxidant and anti-inflammatory properties, on intracerebroventricular streptozotocin (ICV-STZ) induced neuronal loss and memory impairment. To test this hypothesis, male Wistar rats were pretreated with CH (10 and 20 mg/kg bwt) orally once daily for 21 days and then bilaterally injected with ICV-STZ (3 mg/kg bwt), while sham group rats receive the same volume of vehicle. After 2 weeks of ICV-STZ infusion, rats were tested for cognitive performance using Morris water maze (MWM) test and then sacrifice for biochemical and histopathological assays. CH was found to be successful in upregulating the antioxidant status and prevented the memory loss. The expression of choline acetyl transferase (ChAT) was decreased in ICV-STZ group and CH pretreatment increases the expression of ChAT. Moreover, inflammatory mediators like TNF-α, IL-1β levels and expression of iNOS were significantly attenuated by CH pretreatment. The study suggests that CH is effective in preventing memory loss, ameliorating the oxidative stress and might be beneficial for the treatment of sporadic dementia of Alzheimer's type (SDAT).
机译：阿尔茨海默氏病（AD）是一种进行性神经退行性疾病，导致认知能力下降和大脑氧化负荷增加。黄酮类化合物被认为具有抗氧化和抗炎特性，对人体健康有益。本研究旨在阐明儿茶素水合物（CH）（一种具有潜在抗氧化剂和抗炎特性的天然类黄酮）对脑室内链脲佐菌素（ICV-STZ）引起的神经元丢失和记忆障碍的神经保护作用。为了验证这一假设，雄性Wistar大鼠每天口服CH（10和20 mg / kg bwt）预处理21天，然后双侧注射ICV-STZ（3 mg / kg bwt），而假手术组大鼠接受相同的剂量车辆数量。输注ICV-STZ 2周后，使用莫里斯水迷宫（MWM）测试测试大鼠的认知能力，然后处死以进行生化和组织病理学分析。 CH被发现可以成功地上调抗氧化剂的状态并防止记忆丧失。 ICV-STZ组胆碱乙酰基转移酶（ChAT）的表达降低，而CH预处理可增加ChAT的表达。此外，CH预处理可显着减弱炎症介质，如TNF-α，IL-1β水平和iNOS的表达。研究表明，CH可有效预防记忆力丧失，减轻氧化应激，并可能有益于治疗偶发性阿尔茨海默氏病（SDAT）型痴呆。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号