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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Perspectives on experimental models of serotonin syndrome in zebrafish
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Perspectives on experimental models of serotonin syndrome in zebrafish

机译：斑马鱼5-羟色胺综合征实验模型的观点

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Serotonin syndrome (SS) is a serious life-threatening disorder associated with elevated brain serotonergic function. With the growing use of serotonergic drugs, SS affects a large portion of general population, becoming a major biomedical concern. SS-like behaviors have also been reported in animals following administration of serotonergic drugs. Although clinical and rodent studies have provided significant insight into the etiology of SS, its exact mechanisms and risk factors remain poorly understood. The need to develop more efficient psychotropic drugs also requires extensive high-throughput screening of novel compounds using sensitive in-vivo tests. The use of zebrafish (Danio rerio) in neuroscience research is rapidly expanding due to their homology to humans, robust behavioral and physiological responses, genetic tractability, and low costs. Here we discuss the potential of zebrafish models to study SS-related phenotypes induced by selected serotonergic drugs. Overall, zebrafish exposed to serotonergic agents and their combinations exhibit a characteristic top dwelling (surfacing behavior) and hypolocomotion which may represent potential markers of SS-like states in zebrafish. This behavior in zebrafish models positively correlates with brain concentrations of serotonin, suggesting the developing utility of zebrafish (and other aquatic models) for studying SS. Future research is expected to foster high-throughput screening of drug interactions, and pharmacogenetics studies identifying zebrafish mutations implicated in pathological SS-like states.
机译：血清素综合征（SS）是一种严重的威胁生命的疾病，与脑血清素能功能的升高有关。随着血清素能药物的日益普及，SS影响了很大一部分普通人群，成为主要的生物医学问题。血清素能药物给药后在动物中也有类似SS的行为报道。尽管临床和啮齿动物研究对SS的病因学提供了重要的见识，但对其确切的机制和危险因素仍然知之甚少。对开发更有效的精神药物的需求还要求使用敏感的体内试验对新型化合物进行大量的高通量筛选。斑马鱼（Danio rerio）在神经科学研究中的用途由于与人类的同源性，强大的行为和生理反应，遗传易处理性以及低成本而在迅速扩展。在这里，我们讨论了斑马鱼模型研究选择性血清素能药物诱导的SS相关表型的潜力。总体而言，暴露于血清素能药物及其组合的斑马鱼表现出特征性的顶部驻留（表面行为）和运动不足，这可能代表斑马鱼中SS样状态的潜在标记。斑马鱼模型中的这种行为与脑内血清素的含量呈正相关，这表明斑马鱼（和其他水生模型）在研究SS方面的发展实用性。预计未来的研究将促进对药物相互作用的高通量筛选，并且药物遗传学研究将鉴定与病理性SS样状态有关的斑马鱼突变。

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