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首页> 外文期刊>Neurobiology of learning and memory >Dietary cholesterol degrades rabbit long term memory for discrimination learning but facilitates acquisition of discrimination reversal
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Dietary cholesterol degrades rabbit long term memory for discrimination learning but facilitates acquisition of discrimination reversal

机译：饮食中的胆固醇会降低兔子的长期记忆能力，从而促进歧视学习，但有助于逆转歧视

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We have shown previously that feeding dietary cholesterol before learning can improve acquisition whereas feeding cholesterol after learning can degrade long term memory. To examine these different findings within a single paradigm, we fed groups of rabbits 2% cholesterol or normal chow with or without 0.12. ppm copper added to the drinking water following two-tone discrimination learning of the nictitating membrane response in which a 8-kHz tone (conditioned stimulus, CS+) was followed by air puff and a 1-kHz tone (CS-) was not. After eight weeks on the diet, we assessed the rabbits' conditioned responding during testing and retraining. We then reversed the two-tone discrimination and assessed responding to the 1-kHz tone CS+. and the 8-kHz CS-. During testing, rabbits given cholesterol without copper had lower levels of responding to CS+. than rabbits in the other groups suggesting they did not retain the discrimination as well. However, during a brief discrimination retraining session, their response levels to the CS+. returned to the level of the other groups, demonstrating a return of the memory of the original discrimination. At the end of discrimination reversal, these same rabbits exhibited superior discrimination indexed by lower response levels to CS- but similar levels to CS+, suggesting they were better able to acquire the new relationship between the two tones by inhibiting CS- responses. These results add to our previous data by showing cholesterol diet-induced degradation of an old memory and facilitation of a new memory can both be demonstrated within a discrimination reversal paradigm. Given discrimination reversal is a hippocampally-dependent form of learning, the data support the role of cholesterol in modifying hippocampal function as we have shown previously with in vitro brain slice recordings.
机译：先前我们已经表明，在学习之前进食饮食胆固醇可以改善获得能力，而在学习之后进食胆固醇可以降低长期记忆。为了在单个范例中检查这些不同的发现，我们给每组兔子饲喂2％胆固醇或正常食物（含或不含0.12）的兔子。在对烟熏膜反应进行两声辨别学习后，向饮用水中添加了ppm铜，其中在吹气之后跟随了8 kHz声调（条件刺激，CS +），而没有吹气则是1-kHz声调。饮食八周后，我们评估了兔子在测试和再训练期间的条件反应。然后，我们推翻了两个音色的识别，并评估了对1-kHz音色CS +的响应。和8 kHz CS-。在测试过程中，接受不含铜胆固醇的兔子对CS +的反应水平较低。相比其他组中的兔子，这表明它们也没有保留歧视。但是，在简短的歧视再培训期间，他们对CS +的反应水平。回到了其他群体的水平，表明了对原始歧视记忆的回归。在辨别逆转结束时，这些相同的兔子表现出较高的辨别力，其对CS-的响应水平较低，但与CS +的水平相似，表明它们通过抑制CS-响应能够更好地获得两种音调之间的新关系。这些结果通过显示胆固醇饮食引起的旧记忆退化和新记忆促进，在歧视逆转范式中都得到了证明，从而增加了我们以前的数据。鉴于歧视逆转是海马依赖性学习的一种形式，正如我们先前在体外脑切片记录中所显示的那样，数据支持胆固醇在改变海马功能中的作用。

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