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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study
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Acute desipramine treatment reduces regional serotonin synthesis rates, while chronic treatment elevates rates, in a rat model of depression: An autoradiographic study

机译：在抑郁症的大鼠模型中，急性地昔帕明治疗降低了局部5-羟色胺的合成速率，而长期治疗则提高了该比例：一项放射自显影研究

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It has been suggested that 5-HT (serotonin; 5-hydroxytryptamine) and/or the norepinephrine receptor adaptive processes in the brain are the basis for the efficacy of antidepressant treatments, including electro-convulsive shock therapy. In the present study, the effect of acute (10 mg/kg; i.p. injection) and chronic (10 mg/kg/day; delivered by subcutaneous mini-pump) desipramine treatments on regional 5-HT synthesis were evaluated in the Flinders Sensitive Line (FSL; "depressed" rats), as well as the control Flinders Resistant Line (FRL), of rats, using a-[~(14)C]methyl-L-tryptophan autoradiography. The control rats in each of the strains received the same volume (volume in which drug was dissolved) of saline (whether through an injection or, in the case of the chronic experiments, via an osmotic mini-pump), while the treated rats received desipramine (DMI) dissolved in saline (again, as an i.p. injection or by osmotic mini-pump). The rats were randomly assigned to different groups. The results indicate that acute treatment produces a reduction in regional 5-HT synthesis in both the FSL and FRL rats, while chronic treatment produces an elevation of regional 5-HT synthesis in both strains, but the effect was somewhat greater in the FRL rats. When comparing these results to those of normal Sprague-Dawley rats, our results suggest that it is more informative to study 5-HT synthesis in an animal model of depression.
机译：已经提出，脑中的5-HT（5-羟色胺; 5-羟色胺）和/或去甲肾上腺素受体适应性过程是抗抑郁药治疗（包括电惊厥性休克疗法）功效的基础。在本研究中，Flinders Sensitive Line评估了急性（10 mg / kg;腹腔注射）和慢性（10 mg / kg /天;通过皮下微型泵给药）地昔帕明治疗对局部5-HT合成的影响。 （α-[〜（14）C]甲基-L-色氨酸放射自显影术（FSL;“抑郁”的大鼠）以及对照抗弗林德氏系（FRL）。每种菌株中的对照大鼠接受相同体积（溶解药物的体积）的盐水（无论是通过注射，还是在慢性实验的情况下，通过渗透微型泵），而接受治疗的大鼠接受地昔帕明（DMI）溶解在盐水中（再次，作为腹膜内注射或通过渗透微型泵）。将大鼠随机分为不同的组。结果表明，急性治疗在FSL和FRL大鼠中均降低了区域5-HT的合成，而长期治疗在两种品系中均提高了区域5-HT的合成，但在FRL大鼠中其作用更大。当将这些结果与正常Sprague-Dawley大鼠的结果进行比较时，我们的结果表明，在抑郁症动物模型中研究5-HT合成更具参考价值。

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