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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >The lumped constant of a-methyl-L-tryptophan is not influenced by drugs acting through serotonergic system
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The lumped constant of a-methyl-L-tryptophan is not influenced by drugs acting through serotonergic system

机译：α-甲基-L-色氨酸的集总常数不受通过血清素能系统起作用的药物的影响

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摘要

Lumped constant (LC) is a constant used to convert brain trapping constant of a-methyl-L-tryptophan (using a-14C-methyl-L-tryptophan) into the constant for conversion of tryptophan into serotonin (5-hydroxytryptamine, 5-HT), which can be then used with certain assumptions in the calculation of the brain regional 5-HT synthesis rate. The aim of the present study was to investigate the acute effects of two drugs on the regional stability of the LC and possible effect on its value. Drugs used were a selective 5-HT reuptake inhibitor, fluoxetine, and a drug that releases 5-HT and inhibits 5-HT uptake, d,l-fenfluramine. The values of the LC from those experiments were compared with the value of LC obtained in the saline treated rats. KT is the constant for tryptophan conversion into 5-HT, which was measured by an autoradiographic method in more than twenty brain regions, using labelled tryptophan (~(14)C-Trp) as tracer, after the fraction incorporated into proteins was removed. The trapping constant K_a for a-methyl-L-tryptophan was also measured autoradiographically in a separate group of rats. All measurements were done in drug and saline (control) treated rats. The regional LC constants were calculated as the ratios between KT and K_a. Statistical evaluation showed that the regional values in each of these three sets were normally distributed, and that the three sets of LC values calculated as the mean of logarithmic differences (saline 0.450 +-0.055; fluoxetine 0.429 +-0.091; D,L-fenfluramine 0.48 +-0.09) did not differ significantly. The overall weighted mean value of the LC from all three sets of measurements was 0.452 +-0.041, and this value was not significantly different from the LC value of 0.42 +-0.07, i.e. value obtained in our previous studies. These results showed the unaltered LC value in discrete rat brain regions after treatment with fluoxetine or D,L-fenfluramine, and confirmed that the numerical value of the LC used in our previous studies was not a...
机译：集总常数（LC）是用于将a-甲基-L-色氨酸（使用a-14C-甲基-L-色氨酸）的脑诱捕常数转换为用于将色氨酸转化为5-羟色胺（5-羟色胺，5- HT），然后可以在计算脑区域5-HT合成率时使用某些假设。本研究的目的是研究两种药物对LC区域稳定性的急性影响及其可能的价值。使用的药物是选择性的5-HT再摄取抑制剂氟西汀和释放5-HT并抑制5-HT摄取的药物d，1-芬氟拉明。将来自那些实验的LC值与在盐水处理的大鼠中获得的LC值进行比较。 KT是色氨酸转化成5-HT的常数，在将结合到蛋白质中的部分除去后，使用标记的色氨酸（〜（14）C-Trp）作为示踪剂，通过放射照相法在二十多个大脑区域中进行了测量。还通过放射自显影在另一组大鼠中测量了α-甲基-L-色氨酸的俘获常数K_a。所有测量均在药物和生理盐水（对照组）大鼠中进行。计算区域LC常数作为KT和K_a之比。统计评估表明，这三组中的每组的区域值均呈正态分布，并且三组LC值计算为对数差异的平均值（盐水0.450 + -0.055;氟西汀0.429 + -0.091; D，L-芬氟拉明0.48 + -0.09）没有显着差异。来自所有三组测量的LC的总加权平均值为0.452 + -0.041，并且该值与0.42 + -0.07的LC值（即我们先前研究中获得的值）没有显着差异。这些结果表明，在用氟西汀或D，L-芬氟拉明治疗后，大鼠离散脑区域的LC值未发生变化，并证实了我们先前研究中使用的LC的数值不是...

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