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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >New players in the neurovascular unit: Insights from experimental and clinical epilepsy
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New players in the neurovascular unit: Insights from experimental and clinical epilepsy

机译：神经血管单元的新参与者：来自实验和临床癫痫的见解

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摘要

The conventional notion that neurons are exclusively responsible for brain signaling is increasingly challenged by the idea that brain function in fact depends on a complex interplay between neurons, glial cells, vascular endothelium, and immune-related blood cells. Recent data demonstrates that neuronal activity is profoundly affected by an entire cellular and extracellular 'orchestra', the so-called neurovascular unit (NVU). Among the 'musical instruments' of this orchestra, there may be molecules long-known in biomedicine as important mediators of inflammatory and immune responses in the organism, as well as non-neuronal cells, e.g., leukocytes. We here review recent evidence on the structure and function of the NVU, both in the healthy brain and in pathological conditions, such as the abnormal NVU activation observed in epilepsy. We will argue that a better understanding of NVU function will require the addition of new players to the 'orchestra'.
机译：关于神经功能实际上取决于神经元，神经胶质细胞，血管内皮和免疫相关血细胞之间复杂相互作用的观点，越来越多的传统观念认为，神经元只负责大脑的信号传导。最新数据表明，整个细胞和细胞外“乐团”（即所谓的神经血管单位（NVU））对神经元的活动产生了深远的影响。在该乐团的“乐器”中，可能存在生物医学中众所周知的分子，这些分子是生物体以及非神经元细胞（例如白细胞）中炎症和免疫反应的重要介体。我们在这里回顾了有关在健康的大脑和病理状况下NVU的结构和功能的最新证据，例如在癫痫病中观察到的NVU异常激活。我们将争辩说，对NVU功能的更好理解将需要在“乐团”中增加新的演奏者。

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