...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurobiology of disease >Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules
【24h】

Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules

机译：用于分子和药物干预的精神分裂症动物模型和潜在的候选分子

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Schizophrenia is a severe and common psychiatric disease with a lifetime prevalence of 0.5% to 1% globally. Because of limitations of the experimental approach in humans, valid animal models are essential in the effort to identify novel therapeutics for schizophrenia. In most animal models of schizophrenia, second generation antipsychotic drugs are reported to be effective in ameliorating behavioral abnormalities, while clinical evidence indicates that some of the patients are resistant to the antipsychotic drug therapy. Accordingly, animal models of antipsychotic drug-resistant schizophrenia are needed for screening of novel agents that may be more effective than the existing antipsychotic drugs. Furthermore, utilization of appropriate behavioral tasks with reference to human testing is essential to facilitate the development of novel pharmacotherapeutic approaches for the treatment in schizophrenia. Experimental data suggest that there are different types of potential candidate molecules as novel antipsychotic drugs with some therapeutic effects on negative symptoms and cognitive deficits in schizophrenia. It is proposed that to develop novel antipsychotic drugs the efficacy of potential candidate molecules should be evaluated using animal models for treatment-resistant schizophrenia with appropriate behavioral tasks in reference to human testing. ? 2012 Elsevier Inc.
机译：精神分裂症是一种严重且常见的精神疾病，全球终生患病率为0.5％至1％。由于人类实验方法的局限性，有效的动物模型对于确定精神分裂症的新疗法至关重要。据报道，在大多数精神分裂症动物模型中，第二代抗精神病药可有效改善行为异常，而临床证据表明，某些患者对抗精神病药疗法有抵抗力。因此，需要抗精神病药抗性精神分裂症的动物模型来筛选可能比现有抗精神病药更有效的新型药物。此外，参考人类测试适当的行为任务对于促进精神分裂症治疗新药物治疗方法的开发至关重要。实验数据表明，有不同类型的潜在候选分子作为新型抗精神病药，对精神分裂症的阴性症状和认知缺陷有一定的治疗作用。建议开发新的抗精神病药，应使用具有适当行为任务的动物模型对具有抗药性的精神分裂症进行动物模型评估潜在候选分子的功效，并参考人体试验。 ？ 2012爱思唯尔公司

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号