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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Response of hippocampal mossy fiber zinc to excessive glutamate release.
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Response of hippocampal mossy fiber zinc to excessive glutamate release.

机译：海马苔藓纤维锌对过量谷氨酸释放的反应。

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摘要

The response of hippocampal mossy fiber zinc to excessive glutamate release was examined to understand the role of the zinc in excessive excitation in the hippocampus. Extracellular zinc and glutamate concentrations during excessive stimulation with high K(+) were compared between the hippocampal CA3 and CA1 by the in vivo microdialysis. Zinc concentration in the CA3 was more increased than that in the CA1, while glutamate concentration in the CA3 was less increased than that in the CA1. It is likely that more increase in extracellular zinc is linked with less increase in extracellular glutamate in the CA3. To see zinc action in mossy fiber synapses during excessive excitation, furthermore, 1mM glutamate was regionally delivered to the stratum lucidum in the presence of zinc or CaEDTA, a membrane-impermeable zinc chelator, and intracellular calcium signal was measured in the CA3 pyramidal cell layer. The persistent increase in calcium signal during stimulation with glutamate was significantly attenuated in the presence of 100 microM zinc, while significantly enhanced in the presence of 1mM CaEDTA. These results suggest that zinc released from mossy fibers attenuates the increase in intracellular calcium signal in mossy fiber synapses and postsynaptic CA3 neurons after excessive inputs to dentate granular cells.
机译：检查海马苔藓纤维锌对过量谷氨酸释放的反应，以了解锌在海马体过度兴奋中的作用。通过体内微透析比较了海马CA3和CA1在高K（+）过度刺激期间细胞外锌和谷氨酸的浓度。与CA1相比，CA3中的锌浓度增加更多，而与CA1相比，CA3中的谷氨酸浓度增加较少。在CA3中，细胞外锌的更多增加与细胞外谷氨酸的增加较少相关。为了观察在过度激发期间苔藓纤维突触中的锌作用，此外，在存在锌或CaEDTA，膜不渗透性锌螯合剂的情况下，将1mM谷氨酸区域性地传递至透明层，并在CA3锥体细胞层中测量了细胞内钙信号。在存在100 microM锌的情况下，谷氨酸刺激过程中钙信号的持续增加显着减弱，而在存在1mM CaEDTA的情况下显着增强。这些结果表明，从苔藓纤维中释放出的锌会减弱苔藓纤维突触和突触后CA3神经元中细胞内钙信号的增加，而齿状细胞的投入过多。

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