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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Differential temporal response of hippocampus, cortex and cerebellum to hypobaric hypoxia: a biochemical approach.
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Differential temporal response of hippocampus, cortex and cerebellum to hypobaric hypoxia: a biochemical approach.

机译：海马，皮层和小脑对低压缺氧的时空反应差异：一种生化方法。

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Hypobaric hypoxia is known to cause cognitive dysfunctions and memory impairment. The present study aimed at exploring the occurrence of oxidative stress in hypobaric hypoxia and the differential temporal response of the hippocampus, cerebellum following hypobaric hypoxia. Animals were divided into control, 3 days, 7 days and 14 days exposure groups and were exposed to an altitude of 25,000 ft. Our study revealed an increase in lactate dehydrogenase activity along with increase in free radical generation and lipid peroxidation. We also noted depletion in the antioxidants and decrease in glutathione reductase and superoxide dismutase activity. There was significant decrease in reduced glutathione levels in the exposure groups when compared to the control which was accompanied by a concomitant increase in oxidized glutathione levels. Increase in glutamate dehydrogenase activity was observed coinciding with the decrease in glutathione levels which was accompanied with an increase in expression of vesicular glutamate transporter. The hippocampus was found to be more vulnerable to hypobaric hypoxia-induced oxidative stress in comparison to the cortex and cerebellum. An interesting observation was the onset of acclimatization on prolonged exposure to hypobaric hypoxia for a period of 14 days. Hypobaric hypoxia was found to affect various regions of the brain differentially and the response of each region varied as a function of time.
机译：众所周知，低压缺氧会导致认知功能障碍和记忆障碍。本研究旨在探讨低压缺氧时氧化应激的发生以及低压缺氧后海马，小脑的时空差异。将动物分为对照组，3天，7天和14天暴露组，并暴露于25,000英尺的高度。我们的研究揭示了乳酸脱氢酶活性的增加以及自由基产生和脂质过氧化作用的增加。我们还注意到抗氧化剂的消耗以及谷胱甘肽还原酶和超氧化物歧化酶活性的降低。与对照组相比，暴露组的谷胱甘肽水平降低显着降低，并伴有氧化型谷胱甘肽水平升高。观察到谷氨酸脱氢酶活性的增加与谷胱甘肽水平的降低相一致，其同时伴随着水泡谷氨酸转运蛋白表达的增加。与皮质和小脑相比，海马被发现更容易遭受低压缺氧引起的氧化应激。有趣的观察是在长期暴露于低压缺氧环境中14天后开始适应环境。低压缺氧被发现会不同程度地影响大脑的各个区域，每个区域的反应随时间变化。

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