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Repairing brain after stroke: a review on post-ischemic neurogenesis.

机译:中风后修复大脑:缺血后神经发生的综述。

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摘要

Stroke is devastating as currently no therapies are available that can prevent stroke-induced neurological dysfunction in humans. With the recent observations that acute insults to adult brain stimulate new neuronal formation in various species of animals, optimism is building for a possible regeneration of stroke-damaged brain. This article reviewed the advances in the understanding of the molecular mechanisms of the various steps of neurogenesis with an emphasis on the endogenous mediators and exogenous promoters of neural progenitor proliferation, migration and survival in the post-ischemic adult brain.
机译:中风是毁灭性的,因为目前尚无可预防中风引起的神经功能障碍的疗法。最近的观察表明,对成年大脑的急性侮辱刺激了各种动物中新的神经元形成,乐观情绪正在为中风受损大脑的可能再生奠定基础。本文回顾了对神经发生各个步骤的分子机制的理解的进展,重点是缺血后成人大脑中神经祖细胞增殖,迁移和存活的内源性介质和外源性启动子。

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