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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Copper and zinc as modulators of neuronal excitability in a physiologically significant concentration range.
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Copper and zinc as modulators of neuronal excitability in a physiologically significant concentration range.

机译：铜和锌在生理上重要的浓度范围内作为神经元兴奋性的调节剂。

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摘要

Evidence from several areas of neuroscience has led to the notion that copper and zinc could be modulators of neuronal excitability. In order to contribute to test this idea, we characterized the changes induced by these divalent metal ions on the extracellularly recorded action potential firing rates of undissociated olfactory epithelium neurons. Our main finding is that at low concentrations, 1-100 nM for Cu(2+) and 1-50 microM for Zn(2+), they induced a concentration dependent increase in the neuronal firing rate. In contrast, at higher concentrations, 1-5 microM for Cu(2+) and 100-500 microM for Zn(2+), they decreased the firing rate. Based on these and previous results of our laboratory we propose that the biphasic effect of Cu(2+) and Zn(2+) exposure on neuronal firing may be explained by the interaction of these ions with high and low affinity sites in sodium channels whose occupancy leads to activation or inhibition of the sodium current, which is consistent with the proposed modulatory role ofthese metal ions on neuronal excitability.
机译：来自神经科学几个领域的证据导致人们认为铜和锌可能是神经元兴奋性的调节剂。为了有助于测试这一想法，我们表征了这些二价金属离子在未解离的嗅觉上皮神经元的细胞外记录动作电位激发速率上引起的变化。我们的主要发现是在低浓度下，Cu（2+）的浓度为1-100 nM，Zn（2+）的浓度为1-50 microM，它们引起神经元放电速率的浓度依赖性增加。相反，在较高浓度下，Cu（2+）为1-5 microM，Zn（2+）为100-500 microM，它们降低了烧结速率。根据我们实验室的这些结果和先前的结果，我们认为，Cu（2+）和Zn（2+）暴露对神经元放电的双相效应可能是由于这些离子与钠通道中高和低亲和力位点的相互作用所解释的。占用导致钠电流的激活或抑制，这与这些金属离子对神经元兴奋性的调节作用相一致。

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