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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >The effect of different maternal deprivation paradigms on the expression of hippocampal glucocorticoid receptors, calretinin and calbindin-D28k in male and female adolescent rats.
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The effect of different maternal deprivation paradigms on the expression of hippocampal glucocorticoid receptors, calretinin and calbindin-D28k in male and female adolescent rats.

机译：不同母体剥夺范例对成年和成年雌性大鼠海马糖皮质激素受体，钙调蛋白和钙结合蛋白-D28k表达的影响。

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摘要

Maternal deprivation (MD) is a well-established protocol used to investigate neurobiological changes that are associated with the etiology of and vulnerability to stress-related diseases in animal models. The resulting psychophysiological effects, the timing and duration of these adverse stimuli, and the method by which they exert their effects on the animals remain unclear. This study characterized differences in the hippocampal expression of glucocorticoid receptors (GRs) and the calcium-binding proteins calretinin (CALR) and calbindin-D28k (CALB) in male and female rats that underwent different MD paradigms during the stress hyporesponsive period (SHRP). Both GRs and the two calcium-binding proteins were much more abundant in females than in males. MD paradigms had a significant effect on CALR and CALB expression in both males and females but affected GR levels only in males. Additionally, expression of the two calcium-binding proteins in the hippocampus responded differently to MD-induced stress, especially in females. Taken together, these results indicate that females are able to modulate their response to stress better than males.
机译：母体剥夺（MD）是一种完善的方案，用于研究与动物模型中与压力相关的疾病的病因和易感性相关的神经生物学变化。尚不清楚由此产生的心理生理效应，这些不利刺激的时机和持续时间，以及它们对动物发挥作用的方法。这项研究的特征是在压力低反应期（SHRP）经历不同MD范式的雄性和雌性大鼠中，糖皮质激素受体（GRs）和钙结合蛋白钙调蛋白（CALR）和钙结合蛋白D28k（CALB）在海马中的表达差异。女性的GR和两个钙结合蛋白都比男性丰富得多。 MD范例对雄性和雌性的CALR和CALB表达都有显着影响，但仅影响雄性的GR水平。此外，海马中两种钙结合蛋白的表达对MD诱导的应激反应不同，特别是在女性中。综上所述，这些结果表明女性比男性能够更好地调节其对压力的反应。

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