Protein homeostasis and aging: Role of ubiquitin protein ligases

JanaN.R.

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Protein homeostasis and aging: Role of ubiquitin protein ligases

机译：蛋白质稳态和衰老：泛素蛋白质连接酶的作用

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Protein homeostasis is fundamental in normal cellular function and cell survival. The ubiquitin-proteasome system (UPS) plays a central role in maintaining the protein homeostasis network through selective elimination of misfolded and damaged proteins. Impaired function of UPS is implicated in normal aging process and also in several age-related neurodegenerative disorders that are characterized by increased accumulation oxidatively modified proteins and protein aggregates. Growing literature also indicate the potential role of various ubiquitin protein ligases in the regulation of aging process by enhancing the degradation of either central lifespan regulators or abnormally folded and damaged proteins. This review mainly focuses on our current understanding of the importance of UPS function in the regulation of normal aging process.

机译：蛋白质稳态是正常细胞功能和细胞存活的基础。泛素-蛋白酶体系统（UPS）在通过选择性消除折叠错误和受损的蛋白质来维持蛋白质稳态网络中起着核心作用。 UPS的功能受损与正常衰老过程有关，也与几种与年龄有关的神经退行性疾病有关，这些疾病的特征是积累的氧化修饰蛋白质和蛋白质聚集体增加。越来越多的文献还表明，各种泛素蛋白连接酶可能通过增强中央寿命调节剂或异常折叠和损坏的蛋白的降解来调节衰老过程。这篇综述主要集中在我们目前对UPS功能在正常老化过程调节中的重要性的理解上。

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《Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry》 |2012年第5期|共5页
作者
JanaN.R.;
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正文语种 eng
中图分类生物化学;
关键词
Aging; Oxidative stress; Proteasome; Protein homeostasis; Ubiquitin; Ubiquitin ligase;

机译：衰老;氧化应激;蛋白酶体;蛋白质稳态;泛素;泛素连接酶;

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1. Protein homeostasis and aging: Role of ubiquitin protein ligases [J] . JanaN.R. Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2012,第5期

机译：蛋白质稳态和衰老：泛素蛋白质连接酶的作用
2. Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases. [J] . Schauvliege R, Janssens S, Beyaert R FEBS letters. . 2006,第19期

机译：在TLR / IL-1R信号传导中，Pellino蛋白比支架蛋白更多：作为新型RING E3-泛素连接酶发挥作用。
3. Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases. [J] . Rotin D, Staub O, Haguenauer Tsapis-R The Journal of Membrane Biology: An International Journal for Studies on the Structure, Function & Genesis of Biomembranes . 2000,第1期

机译：质膜蛋白的泛素化和内吞作用：泛素蛋白连接酶的Nedd4 / Rsp5p家族的作用。
4. Identification of the Binding Domains of Nedd4 E3 Ubiquitin Ligase with Its Substrate Protein TMEPAI [C] . Lei Jing, Xin Huo, Yufeng Li, International conference on applied biotechnology . 2015

机译：Nedd4 E3泛素连接酶及其底物蛋白TMEPAI的结合域的鉴定。
5. A Heuristic Ontological Model of Protein Complexes A Case Study Based on the E3 Ubiquitin Ligase Protein Complexes of Arabidopsis thaliana. [D] . DiNatale, Claudia. 2012

机译：蛋白质复合物的启发式本体模型-基于拟南芥E3泛素连接酶蛋白质复合物的案例研究。
6. Roles of E3 Ubiquitin-Ligases in Nuclear Protein Homeostasis during Plant Stress Responses [O] . Irene Serrano, Laura Campos, Susana Rivas -1

机译：E3泛素-里加斯在植物胁迫响应过程中核蛋白稳态中的作用
7. Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases [O] . Schauvliege, Reinout, Janssens, Sophie, Beyaert, Rudi 2006

机译：pellino蛋白不仅仅是TLR / IL-1R信号传导中的支架蛋白：作为新型RING E3-泛素连接酶的作用

Protein homeostasis and aging: Role of ubiquitin protein ligases

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