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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain
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Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain

机译：在三叉神经性疼痛的啮齿动物模型中，全身性普瑞巴林可减轻面部超敏反应和延髓背角中谷氨酸的有害刺激引起的释放

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摘要

Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullary dorsal horn (MDH) in a rodent model of trigeminal neuropathic pain. Nociceptive mechanical sensitivity was assessed pre-operatively, and then post-operatively 1 h following pregabalin or vehicle (saline) treatment on post-operative days 2 and 5 following infraorbital nerve transection (IONX). In addition, an in vivo microdialysis probe was inserted into the exposed medulla post-operatively and dialysate samples were collected. Glutamate release was then evoked by mustard oil (MO) application to the tooth pulp, and the effects of pregabalin or vehicle were examined on the MDH glutamate release. Glutamate concentrations in the dialysated samples were determined by HPLC, and data analyzed by ANOVA. IONX animals (but not control animals) showed facial mechanical hypersensitivity for several days post-operatively. In addition, tooth pulp stimulation with MO evoked a transient release of glutamate in the MDH of IONX animals. Compared to vehicle, administration of pregabalin significantly attenuated the facial mechanical hypersensitivity as well as the MO-evoked glutamate release in MDH. This study provides evidence in support of recent findings pointing to the usefulness of pregabalin in the treatment of orofacial neuropathic pain.
机译：普瑞巴林有效治疗许多神经性疼痛。但是，其止痛作用的机制仍知之甚少。本研究的目的是确定在三叉神经痛的啮齿动物模型中，普瑞巴林是否能抑制面部机械性超敏反应和诱发髓质背角（MDH）中的谷氨酸释放。术前评估伤害性机械敏感性，然后在眶下神经横切术（IONX）后第2天和第5天，在接受普瑞巴林或媒介（盐水）治疗后1小时进行伤害性机械敏感性评估。另外，在手术后将体内微透析探针插入暴露的髓质，并收集透析液样品。然后，通过在牙髓上涂抹芥末油（MO）诱发谷氨酸释放，并检查普瑞巴林或赋形剂对MDH谷氨酸释放的影响。通过HPLC测定透析样品中的谷氨酸盐浓度，并通过ANOVA分析数据。 IONX动物（但非对照动物）在术后几天表现出面部机械性超敏反应。此外，用MO刺激牙髓可引起IONX动物MDH中谷氨酸的瞬时释放。与媒介物相比，普瑞巴林的给药显着减轻了MDH中面部机械性超敏反应以及MO诱发的谷氨酸释放。这项研究提供证据支持最近的研究结果，指出普瑞巴林在治疗口面部神经性疼痛中的有用性。

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