...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >3beta-HSD activates DHEA in the songbird brain.
【24h】

3beta-HSD activates DHEA in the songbird brain.

机译：3beta-HSD激活鸣禽大脑中的DHEA。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dehydroepiandrosterone (DHEA) is an abundant circulating prohormone in humans, with a variety of reported actions on central and peripheral tissues. Despite its abundance, the functions of DHEA are relatively unknown because common animal models (laboratory rats and mice) have very low DHEA levels in the blood. Over the past decade, we have obtained considerable evidence from avian studies demonstrating that (1) DHEA is an important circulating prohormone in songbirds and (2) the enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD), responsible for converting DHEA into a more active androgen, is expressed at high levels in the songbird brain. Here, we first review biochemical and molecular studies demonstrating the widespread activity and expression of 3beta-HSD in the adult and developing songbird brain. Studies examining neural 3beta-HSD activity show effects of sex, stress, and season that are region-specific. Second, we review studies showing seasonal and stress-related changes in circulating DHEA in captive and wild songbird species. Third, we describe evidence that DHEA treatment can stimulate song behavior and the growth of neural circuits controlling song behavior. Importantly, brain 3beta-HSD and aromatase can work in concert to locally metabolize DHEA into active androgens and estrogens, which are critical for controlling behavior and robust adult neuroplasticity in songbirds. DHEA is likely secreted by the avian gonads and/or adrenals, as is the case in humans, but DHEA may also be synthesized de novo in the songbird brain from cholesterol or other precursors. Irrespective of its source, DHEA seems to be an important prohormone in songbirds, and 3beta-HSD is a key enzyme in the songbird brain.
机译：脱氢表雄酮（DHEA）是人类中丰富的循环激素，据报道对中枢和外周组织有多种作用。尽管DHEA功能丰富，但相对未知，因为常见的动物模型（实验室大鼠和小鼠）血液中的DHEA水平非常低。在过去的十年中，我们从鸟类研究中获得了大量证据，这些证据表明（1）DHEA是鸣禽中重要的循环激素，以及（2）3DH-羟类固醇脱氢酶/异构酶（3beta-HSD），可将DHEA转化为一种活性更高的雄激素在鸣禽的大脑中高水平表达。在这里，我们首先回顾生物化学和分子研究，证明3beta-HSD在成年和发育中的鸣禽大脑中具有广泛的活性和表达。研究神经3beta-HSD活性的研究表明，性别，压力和季节的影响是特定于区域的。其次，我们回顾了显示圈养和野生鸣禽物种中循环DHEA的季节性和压力相关变化的研究。第三，我们描述了DHEA治疗可以刺激歌曲行为和控制歌曲行为的神经回路生长的证据。重要的是，大脑3beta-HSD和芳香化酶可以协同工作，将DHEA局部代谢为活性雄激素和雌激素，这对于控制行为和鸣禽中强大的成年神经可塑性至关重要。 DHEA可能是人的性腺和/或肾上腺分泌的，就像人类一样，但是DHEA也可能从鸟脑中从胆固醇或其他前体从头合成。不论其来源如何，DHEA似乎是鸣禽中的重要激素，而3beta-HSD是鸣禽大脑中的关键酶。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号