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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes.
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Systemic administration of 3-nitropropionic acid points out a different role for active caspase-3 in neurons and astrocytes.

机译：3-硝基丙酸的全身给药指出了神经元和星形胶质细胞中活性caspase-3的不同作用。

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摘要

The intraperitoneal administration of 3-nitropropionic acid, which is commonly used to induce toxicity models of Huntington's disease in experimental animals, produces severe brain injury in the lateral part of the striatum. We studied the presence of active caspase-3 in neurons and astrocytes from brains of rats treated with 3-nitropropionic acid following a subacute administration protocol. Active caspase-3 was almost absent in the core of the striatal lesion. However, it was expressed, albeit weakly, in the neurons present in the rim of the lesion. In cortex and non-injured striatal areas, and in the cortex and striatum of control animals, active caspase-3 staining was widely distributed and vivid, but localized in the cell bodies of astrocytes rather than in neurons. In treated animals, some of the active caspase-3 positive neurons localized in the rim of the lesion were also positive for TUNEL staining. This indicates the presence of a caspase-mediated apoptotic process. TUNEL was not present in control animals or in the astrocytes of treated animals. Thus, the presence of active caspase-3 in astrocytes may be merely constitutive.
机译：腹膜内施用3-硝基丙酸通常用于在实验动物中诱发亨廷顿舞蹈病的毒性模型，会在纹状体的外侧部分造成严重的脑损伤。我们研究了亚急性给药方案后用3-硝基丙酸处理的大鼠大脑神经元和星形胶质细胞中活性caspase-3的存在。纹状体病变的核心几乎没有活性的caspase-3。然而，尽管在病变边缘存在的神经元中微弱地表达了它。在对照动物的皮层和未损伤的纹状体区域以及皮层和纹状体中，活跃的caspase-3染色广泛分布且生动，但位于星形胶质细胞的细胞体而不是神经元。在治疗的动物中，位于病灶边缘的一些活跃的caspase-3阳性神经元对TUNEL染色也呈阳性。这表明存在半胱天冬酶介导的凋亡过程。在对照动物或治疗动物的星形胶质细胞中不存在TUNEL。因此，星形胶质细胞中活性caspase-3的存在可能只是组成性的。

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