...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >The synaptomatrix: a solid though dynamic contact disconnecting transmissions from exocytotic events.
【24h】

The synaptomatrix: a solid though dynamic contact disconnecting transmissions from exocytotic events.

机译：突触突触：一种坚固而动态的接触使细胞与胞吐事件之间的传递断开。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The vesicular hypothesis originally introduced to explain the quantal nature of presynaptic neurotransmitter (NT) release has been initially confirmed by the presence of NT within presynaptic vesicles and by an exo-endocytotic traffic associated with intense synaptic activity. Since then, an increasing number of synaptic transmission properties cannot be readily incorporated into the now popular model in which each quantal NT packet is prepared in a vesicle and is released by diffusion across the synaptic cleft when this vesicle fuses transiently or definitively with the plasma membrane. Interestingly, presynaptic exocytosis exhibits the characteristics of the ubiquitous secretory pathway by which all eukaryotic cells interact with their immediate environment, not just externalizing soluble products, but principally delivering at particular location of the cell surface specific glycoconjugates constituting the extracellular matrix (ECM) that mediates intercellular adhesion, recognition and signaling. Recent studies point to the involvement of vesicular glycoproteins in fast transmission after their incorporation into the transsynaptic ECM, or synaptomatrix. The notion of synaptomatrix is presented as a multimolecular tight arrangement that is dynamically remodeled in a use-dependent fashion via PKC to support synaptic morpho-functional plasticity. The data reviewed suggests that the synaptomatrix controls in a Ca(2+) entry-dependent manner the solubility of the NT in the cleft to support fast transmission.
机译：最初被用来解释突触​​前神经递质（NT）释放的数量性质的水泡假说最初已被突触前囊泡中NT的存在以及与强烈突触活动相关的胞外吞噬交通所证实。从那时起，越来越多的突触传递特性无法轻易整合到现在流行的模型中，在该模型中，每个定量NT包都在囊泡中制备，并且当该囊泡与质膜瞬时融合或确定性融合时，通过跨突触间隙扩散而释放。 。有趣的是，突触前胞吐作用表现出普遍存在的分泌途径的特征，所有真核细胞都通过其分泌途径与其周围环境相互作用，而不仅是使可溶性产物外化，而且主要是在细胞表面的特定位置处传递构成介导细胞外基质（ECM）的特异性糖结合物细胞间粘附，识别和信号传导。最近的研究指出，囊泡糖蛋白掺入经突触的ECM或突触母细胞后，参与了快速传播。突触突触的概念以多分子紧密排列的形式出现，它通过使用依赖方式通过PKC动态重塑，以支持突触形态功能可塑性。审查的数据表明突触基质控制Ca（2+）项依赖方式的NT在裂隙中的溶解度，以支持快速传播。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号