...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Trimethyltin-induced hippocampal degeneration as a tool to investigate neurodegenerative processes
【24h】

Trimethyltin-induced hippocampal degeneration as a tool to investigate neurodegenerative processes

机译：三甲基锡诱导的海马变性作为研究神经变性过程的工具

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively localised in the limbic system and especially marked in the hippocampus, is considered a useful tool to obtain an experimental model of neurodegeneration. Animals exposed to TMT develop behavioural alterations (hyperactivity and aggression), cognitive impairment (memory loss and learning impairment) and spontaneous seizures. TMT induces selective neuronal death involving the granular neurons of the Fascia Dentata and the pyramidal cells of the Cornu Ammonis, with a different pattern of severity and extension according to the various species studied and the dosage schedule. TMT-induced neurodegenerative events are associated with the activation of astrocytes and microglial cells and with the upregulation of proinflammatory cytokines. While the mechanisms by which TMT induces neurodegeneration are still not understood, many hypotheses seem to suggest that neuronal damage could be largely dependent on calcium overload. This review summarizes current data from in vivo and in vitro studies of the neurotoxic effects of TMT, focusing on the hypotheses regarding the mechanisms leading to neuronal death induced by the toxin.
机译：三甲基锡（TMT）是一种具有神经毒性作用的有机锡化合物，选择性地定位在边缘系统中，尤其是在海马中，被认为是获得神经变性实验模型的有用工具。暴露于TMT的动物会出现行为改变（过度活跃和攻击性），认知障碍（记忆力丧失和学习障碍）和自发性癫痫发作。 TMT诱导选择性神经元死亡，涉及齿状筋膜的颗粒神经元和Cornu Ammonis的锥体细胞，根据研究的各种物种和用药时间表，其严重性和延伸方式不同。 TMT诱导的神经退行性事件与星形胶质细胞和小胶质细胞的活化以及促炎性细胞因子的上调有关。虽然仍不清楚TMT诱导神经变性的机制，但许多假设似乎表明神经元损伤可能主要取决于钙超载。这篇综述总结了有关TMT的神经毒性作用的体内和体外研究的最新数据，重点是关于毒素导致神经元死亡的机制的假说。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号