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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Prenatal stress induces alterations in cerebellar nitric oxide that are correlated with deficits in spatial memory in rat's offspring
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Prenatal stress induces alterations in cerebellar nitric oxide that are correlated with deficits in spatial memory in rat's offspring

机译：产前应激会诱发小脑一氧化氮的改变，这与大鼠后代的空间记忆缺陷有关

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摘要

Prenatal stress (PS) has been linked to abnormal cognitive, behavioral and psychosocial outcomes in both animals and humans. Since PS has been shown to induce a cerebellar cytoarchitectural disarrangement and cerebellar abnormalities that have been linked to an impairment of behavioral functions, the aim of the present work was to investigate whether the exposure to PS in a period in which the cerebellum is still immature can induce behavioral deficits in the adult and whether this alterations are correlated with changes in nitric oxide (NO) and cellular oxidative mechanisms in offspring's cerebellum. Our results show impairments in spatial memory and territory discrimination in PS adult rats. PS offspring also displayed alterations in cerebellar nitric oxide synthase (NOS) expression and activity. Moreover, a correlation between spatial memory deficits and the increase in NOS activity was found. The results found here may point to a role of cerebellar NO in the behavioral alterations induced by stress during early development stages.
机译：产前压力（PS）与动物和人类的异常认知，行为和社会心理结果有关。由于已经证明PS会诱发与行为功能受损有关的小脑细胞结构紊乱和小脑异常，因此本研究的目的是调查在小脑仍然不成熟的时期是否可以暴露于PS。诱导成年后的行为缺陷，这种改变是否与后代小脑中一氧化氮（NO）的变化和细胞氧化机制有关。我们的结果表明，成年PS大鼠的空间记忆和区域辨别力受损。 PS后代还表现出小脑一氧化氮合酶（NOS）表达和活性的改变。此外，发现了空间记忆缺陷与NOS活性增加之间的相关性。此处发现的结果可能表明小脑NO在早期发育阶段由压力诱导的行为改变中的作用。

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