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首页> 外文期刊>Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry >Behavioral deficits induced by lead exposure are accompanied by serotonergic and cholinergic alterations in the prefrontal cortex
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Behavioral deficits induced by lead exposure are accompanied by serotonergic and cholinergic alterations in the prefrontal cortex

机译：铅暴露引起的行为缺陷伴有额叶前皮质的血清素能和胆碱能改变

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The effects of long-term lead (Pb) exposure producing a blood Pb concentration of lower than 20 ??g/dL, i.e. below that associated with overt neurological deficits in occupationally exposed individuals, was studied in adult rats. In order to assess gender differences, we performed parallel behavioral experiments in male and female rats. Exposure to Pb acetate (50 ppm in drinking water) for 6 months induced motor and cognitive alterations, however these effects were gender- and task-dependent. Chronic lead exposure impaired spatial learning assessed in the Morris water maze test (MWM) in both genders, whereas it only induced hyperactivity in the open field and impaired motor coordination in the rotarod test, only in male rats. Hyperactivity in male rats was accompanied by an increase in extracellular level of acetylcholine in the prefrontal cortex. Extracellular dopamine concentration in the prefrontal cortex was unaffected by lead exposure whereas serotonin concentration in the same brain area was significantly decreased in both male and female rats exposed to lead. These results unveil new molecular mechanisms underlying neuropsychiatric alterations induced by chronic lead exposure. ? 2013 Published by Elsevier Ltd.
机译：在成年大鼠中研究了长期铅（Pb）暴露产生的血液Pb浓度低于20μg/ dL，即低于与职业暴露个体的明显神经系统缺陷有关的影响。为了评估性别差异，我们在雄性和雌性大鼠中进行了平行行为实验。暴露于乙酸铅中（饮用水中50 ppm）6个月可引起运动和认知改变，但是这些影响取决于性别和任务。长期暴露于铅会损害两种性别的莫里斯水迷宫测试（MWM）中评估的空间学习，而仅在雄性大鼠中，它会在露天场所诱发过度活跃，并在旋转脚架测试中损害运动协调能力。雄性大鼠多动症伴随着额叶前额叶皮质中乙酰胆碱的细胞外水平增加。铅暴露不影响额叶前额叶皮层中的细胞外多巴胺浓度，而暴露于铅的雄性和雌性大鼠在相同大脑区域的血清素浓度均显着降低。这些结果揭示了由慢性铅暴露引起的神经精神改变的潜在新分子机制。 ？ 2013由Elsevier Ltd.出版

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