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首页> 外文期刊>Neurobiology of learning and memory >Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: the role of hippocampal brain-derived neurotrophic factor.
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Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: the role of hippocampal brain-derived neurotrophic factor.

机译：自愿运动可减轻吗啡依赖大鼠的认知功能障碍：海马脑源性神经营养因子的作用。

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Chronic exposure to opiates impairs spatial learning and memory. Given the well-known beneficial effects of voluntary exercise on cognitive functions, we investigated whether voluntary exercise would ameliorate the cognitive deficits that are induced by morphine dependence. If an effect of exercise was observed, we aimed to investigate the possible role of hippocampal brain-derived neurotrophic factor (BDNF) in the exercise-induced enhancement of learning and memory in morphine-dependent rats. The rats were injected with bi-daily doses (10mg/kg, at 12h intervals) of morphine over a period of 10 days of voluntary exercise. Following these injections, a water maze task was performed twice a day for five consecutive days, followed by a probe trial 2 days later. A specific BDNF inhibitor (TrkB-IgG chimera) was used to block the hippocampal BDNF action during the 10 days of voluntary exercise. We found that voluntary exercise blocked the ability of chronic morphine to impair spatial memory retention. A blockade of the BDNF action blunted the exercise-induced improvement of spatial memory in the dependent rats. Moreover, the voluntary exercise diminished the severity of the rats' dependency on morphine. This study demonstrates that voluntary exercise ameliorates, via a TrkB-mediated mechanism, the cognitive deficits that are induced by chronic morphine. Thus, voluntary exercise might be a potential method to ameliorate some of the deleterious behavioral consequences of the abuse of morphine and other opiates.
机译：长期接触鸦片会损害空间学习和记忆能力。鉴于自愿运动对认知功能的众所周知的有益影响，我们研究了自愿运动是否会减轻吗啡依赖性诱发的认知缺陷。如果观察到运动的效果，我们旨在调查海马脑源性神经营养因子（BDNF）在运动诱导的吗啡依赖性大鼠学习和记忆增强中的可能作用。在为期10天的自愿运动中，大鼠每两天注射一次吗啡（10mg / kg，间隔12h）。这些注射后，连续两次连续五天每天两次执行水迷宫任务，然后在两天后进行探针试验。在自愿运动的10天中，使用了特定的BDNF抑制剂（TrkB-IgG嵌合体）来阻断海马BDNF的作用。我们发现自愿运动会阻碍慢性吗啡损害空间记忆保持能力。 BDNF作用的阻滞减弱了运动引起的依赖大鼠空间记忆的改善。此外，自愿锻炼减轻了大鼠对吗啡依赖性的严重性。这项研究表明，自愿运动通过TrkB介导的机制改善了慢性吗啡引起的认知缺陷。因此，自愿锻炼可能是减轻滥用吗啡和其他鸦片制剂的某些有害行为后果的潜在方法。

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