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首页> 外文期刊>Neurobiology of learning and memory >Intra-perirhinal cortex administration of estradiol, but not an ER beta agonist, modulates object-recognition memory in ovariectomized rats
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Intra-perirhinal cortex administration of estradiol, but not an ER beta agonist, modulates object-recognition memory in ovariectomized rats

机译：雌二醇的腹膜内皮质给药而非ERβ激动剂可调节卵巢切除大鼠的对象识别记忆

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摘要

Intra-rhinal cortical infusion of 17-beta estradiol (E2, 244.8 pg/mu l) enhances performance on the Novel-Object Preference (NOP) test and impairs accuracy on the delayed nonmatching-to-sample (DNMS) task in the same set of ovariectomized rats (Gervais, Jacob, Brake, & Mumby, 2013). These results appear paradoxical, as normal performance on both tests require intact object-recognition memory (ORM) ability. While demonstrating a preference for the novel object requires recognizing the sample object, rodents can recognize the sample object and still fail to demonstrate a preference. Therefore, enhanced NOP test performance is consistent with both improved ORM and increased novel-object exploration independent of memory processes. There is some evidence suggesting that estrogen receptor (ER) beta agonists enhance NOP test performance (Jacome et al., 2010), but no study to date has examined the role of this receptor in DNMS task performance in rodents. The aim of the present study was to determine whether intra-PRh infusion of an ER beta agonist, diarylpropionitrile (DPN, 2 mu g/mu l), has divergent effects on novel-object preference (i.e. novelty preference) and accuracy on the DNMS task. Ovariectomized (OVX) rats (n = 7) received chronic low E2 (similar to 22 pg/ml serum) replacement, then intra-PRh infusion of DPN (2 mu g/mu l), E2 (244.8 pg/mu l), or vehicle before each mixed-delay session (0.5-5 min) of the DNMS task. A different set of OVX rats (n = 10) received the same infusions before each NOP test trial, and were tested either 4 or 72 h later. Consistent with Gervais et al. (2013), intra-PRh E2 reduced accuracy on the DNMS task following a 5-min retention delay and enhanced novelty preference on both tests. Intra-PRh DPN was associated with accuracy that was similar to the vehicle-infusion condition, despite enhancing novelty preference on both tests. The accuracy results suggest that while intra-PRh E2 impairs ORM, ER beta does not play a role. However, ER beta in the PRh appears to be important for the expression of novelty preference, in a manner that is unaffected by retention delay. These findings suggest that the modulation of novelty preference by intra-PRh E2/ER beta may be due to factors unrelated to ORM. (C) 2016 Elsevier Inc. All rights reserved.
机译：鼻内皮层注射17-β雌二醇（E2，244.8 pg /μl）可以提高新对象偏好（NOP）测试的性能，并削弱同一组中的延迟不匹配样品（DNMS）任务的准确性切除卵巢的大鼠（Gervais，Jacob，Brake和Mumby，2013年）。这些结果似乎是自相矛盾的，因为两种测试的正常性能都需要完整的对象识别记忆（ORM）能力。证明对新颖对象的偏爱需要识别样本对象，而啮齿动物可以识别样本对象，但仍然无法证明偏爱。因此，增强的NOP测试性能与改进的ORM和独立于存储过程的新颖对象探索都一致。有证据表明，雌激素受体（ER）β激动剂可增强NOP测试性能（Jacome等，2010），但迄今为止尚无研究检查该受体在啮齿动物中DNMS任务表现中的作用。本研究的目的是确定ERβ激动剂二芳基丙腈（DPN，2μg/μl）的PRh内输注是否对新颖对象偏好（即新颖性偏好）和DNMS准确性产生不同的影响任务。去卵巢（OVX）大鼠（n = 7）接受慢性低E2（类似于22 pg / ml血清）置换，然后PRh内注入DPN（2μg /μl），E2（244.8 pg /μl），或DNMS任务的每个混合延迟会话（0.5-5分钟）之前的车辆。在每个NOP测试试验之前，另一组OVX大鼠（n = 10）接受了相同的输注，并在4或72小时后进行了测试。与Gervais等人一致。 （2013），PRh内E2保留5分钟后，DNMS任务的准确性降低，并且两种测试的新颖性均得到增强。尽管两种测试均提高了新颖性，但PRh内DPN的准确性与溶媒注入条件相似。准确性结果表明，尽管PRh内E2会损害ORM，但ER beta不会发挥作用。但是，PRh中的ER beta似乎对于表达新颖性偏好很重要，其方式不受保留延迟的影响。这些发现表明PRh内E2 / ERβ对新颖性偏好的调节可能是由于与ORM不相关的因素所致。 （C）2016 Elsevier Inc.保留所有权利。

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