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首页> 外文期刊>Neurogastroenterology and motility >Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS
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Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS

机译：IBS患儿在不同肠道部位的神经免疫相互作用与腹痛症状有关

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Background: Neuroimmune interactions and inflammation have been proposed as factors involved in sensory-motor dysfunction and symptom generation in adult irritable bowel syndrome (IBS) patients. In children with IBS and healthy controls, we measured ileocolonic mast cell infiltration and fecal calprotectin and evaluated the relationships between these parameters and abdominal pain symptoms and stooling pattern. Methods: Irritable bowel syndrome patients diagnosed according to Pediatric Rome III criteria and healthy controls kept a 2-week pain/stooling diary. Ileocolonic mucosal mast cells (MC) and MC in close proximity to nerve fibers (MC-NF) were identified immunohistochemically and quantified. Fecal calprotectin concentration was measured. Key Results: 21 IBS patients and 10 controls were enrolled. The MC-NF count was significantly higher in the ileum (p = 0.01), right colon (p = 0.04), and left colon (p 0.001) of IBS patients compared with controls. No differences in fecal calprotectin concentration were noted. Abdominal pain intensity score correlated with ileal MC count (rs = 0.47, p = 0.030) and right colon MC-NF count (rs = 0.52, p = 0.015). In addition, children with IBS with 3 abdominal pain episodes/week had greater ileal (p = 0.002) and right colonic (p = 0.01) MC counts and greater ileal (p = 0.05) and right colonic (p = 0.016) MC-NF counts than children with less frequent pain. No relationship was found between MC and MC-NF and fecal calprotectin or stooling pattern. Conclusions & Inferences: Mast cells-nerve fibers counts are increased in the ileocolonic mucosa of children with IBS. Mast cells and MC-NF counts are related to the intensity and frequency of abdominal pain. The relevance of mast cells and neuroimmune interaction in children with IBS is still unknown. We assessed in the ileal and colonic mucosa of children with IBS mast cell infiltration, mast cell-nerve interactions, and their correlations with symptoms. The number of mast cells in close proximity to nerves both in the ileal and colonic mucosa was increased and related to the intensity and frequency of abdominal pain.
机译：背景：已提出神经免疫相互作用和炎症是成人肠易激综合征（IBS）患者感觉运动功能障碍和症状产生的相关因素。在患有IBS和健康对照的儿童中，我们测量了回结肠结肠肥大细胞浸润和粪便钙卫蛋白，并评估了这些参数与腹痛症状和粪便模式之间的关系。方法：根据小儿罗马III标准诊断的肠易激综合征患者和健康对照者保留2周的疼痛/便便日记。免疫组织化学鉴定并定量了结肠结肠粘膜肥大细胞（MC）和紧邻神经纤维的MC（MC-NF）。测量粪便钙卫蛋白的浓度。关键结果：招募了21名IBS患者和10名对照。与对照组相比，IBS患者的回肠（p = 0.01），右结肠（p = 0.04）和左结肠（p <0.001）的MC-NF计数显着更高。粪便钙卫蛋白浓度没有差异。腹部疼痛强度评分与回肠MC计数（rs = 0.47，p = 0.030）和右结肠MC-NF计数（rs = 0.52，p = 0.015）相关。此外，IBS患儿每周腹痛发作次数> 3，回肠（p = 0.002）和右结肠（p = 0.01）的MC计数较高，回肠（p = 0.05）和右结肠（p = 0.016）的MC-计数较高。 NF的计数比疼痛少的儿童多。没有发现MC和MC-NF与粪钙卫蛋白或粪便形态之间的关系。结论与推断：IBS患儿回结肠黏膜的肥大细胞神经纤维数量增加。肥大细胞和MC-NF计数与腹痛的强度和频率有关。 IBS患儿肥大细胞和神经免疫相互作用的相关性仍未知。我们评估了患有IBS肥大细胞浸润，肥大细胞-神经相互作用及其与症状的相关性的儿童的回肠和结肠黏膜。回肠和结肠粘膜中靠近神经的肥大细胞数量增加，并且与腹痛的强度和频率有关。

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