The effect of neuronal activity and connectivity on Alzheimer's disease: a new direction and its implications for future treatment strategies

Willem de Haan

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The effect of neuronal activity and connectivity on Alzheimer's disease: a new direction and its implications for future treatment strategies

机译：神经元活动和连接性对阿尔茨海默氏病的影响：一个新的方向及其对未来治疗策略的影响

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Imagine troubleshooting a malfunctioning computer without turning it on or paying attention to the software installed on it. Imagine trying to understand traffic jams without looking at actual traffic flow, or the spread of epidemics without paying attention to human travel patterns. These approaches seem shortsighted, since 'dynamics' form an essential aspect of these systems, often influencing or even causing vulnerability and malfunction. Yet, this is exactly what is happening presently in Alzheimer's disease (AD) research, as the brain's core business, the coordination of neuronal communication, is largely ignored.

机译：想象一下，对一台发生故障的计算机进行故障排除而无需打开计算机或注意计算机上安装的软件。想象一下，在不了解实际交通流量的情况下尝试了解交通拥堵，或者在不关注人类出行方式的情况下了解流行病的传播情况。这些方法似乎是短视的，因为“动力学”是这些系统的重要方面，通常会影响甚至导致漏洞和故障。然而，这正是阿尔茨海默氏病（AD）研究中正在发生的事情，因为大脑的核心业务，神经元沟通的协调在很大程度上被忽略了。

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《Neurodegenerative disease management》 |2013年第2期|共3页
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Willem de Haan;
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中图分类神经病学与精神病学;
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1. The effect of neuronal activity and connectivity on Alzheimer's disease: a new direction and its implications for future treatment strategies [J] . Willem de Haan Neurodegenerative disease management . 2013,第2期

机译：神经元活动和连接性对阿尔茨海默氏病的影响：一个新的方向及其对未来治疗策略的影响
2. Detouring destruction: a role for inhibitory neuronal activity in preventing neuronal loss--implications for Alzheimer's disease [J] . RA Graf JAOA: The Journal of the American Osteopathic Association . 2001,第12asuppla1期

机译：绕行破坏：抑制神经元活动在预防神经元丢失中的作用-对阿尔茨海默氏病的意义
3. Human Neural Stem Cell Transplantation Rescues Cognitive Defects in APP/PS1 Model of Alzheimer’s Disease by Enhancing Neuronal Connectivity and Metabolic Activity [J] . Xueyuan Li, Hua Zhu, Xicai Sun, Frontiers in Aging Neuroscience . 2016,第3期

机译：人类神经干细胞移植通过增强神经元连通性和代谢活性来挽救阿尔茨海默氏病APP / PS1模型中的认知缺陷
4. MR Diffusion Tensor Imaging (DTI) and Neuropsychological Testing for Neuronal Connectivity in Alzheimer's Disease (AD) Patients [C] . Jianhui Zhong, Hongyan Ni, Tong Zhu, Physiology, Function, and Structure from Medical Images . 2004

机译：MR扩散张量成像（DTI）和神经心理学测试，用于阿尔茨海默氏病（AD）患者的神经元连接
5. The involvement of metal ions in Alzheimer's disease pathology and implications for diagnosis and treatment [D] . Leskovjan, Andreana Charlotte 2009

机译：金属离子参与阿尔茨海默氏病病理及其对诊断和治疗的意义
6. The Hyperactivity–Impulsivity–Irritiability–Disinhibition–Aggression–Agitation Domain in Alzheimer’s Disease: Current Management and Future Directions [O] . Rachel M. Keszycki, Daniel W. Fisher, Hongxin Dong -1

机译：阿尔茨海默氏病的机能亢进-冲动-易怒-抑制-侵略-焦虑领域：当前的管理和未来方向
7. The effect of neuronal activity and connectivity on Alzheimer’s disease: a new direction and its implications for future treatment strategies [O] . de Haan, W. 2013

机译：神经元活动和连接性对阿尔茨海默氏病的影响：新方向及其对未来治疗策略的影响

The effect of neuronal activity and connectivity on Alzheimer's disease: a new direction and its implications for future treatment strategies

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