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Development of the peripheral glial cells in Drosophila

机译:果蝇周围神经胶质细胞的发育

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In complex organisms the nervous system comprises two cell types: neurons and glial cells. Their correct interplay is of crucial importance during both the development of the nervous system and for later function of the nervous system. In recent years tools have been developed for Drosophila that enable genetic approaches to understanding glial development and differentiation. Focusing on peripheral glial cells we first summarize wild-type development, then introduce some of the relevant genes that have been identified. Despite obvious differences between Drosophila and mammalian glial cells, the molecular machinery that controls terminal differentiation appears well conserved.
机译:在复杂的生物中,神经系统包括两种细胞类型:神经元和神经胶质细胞。它们的正确相互作用在神经系统的发育以及神经系统的后续功能中都至关重要。近年来,已经开发了用于果蝇的工具,这些工具能够通过遗传方法了解神经胶质的发育和分化。着眼于周围神经胶质细胞,我们首先总结了野生型发育,然后介绍了一些已鉴定的相关基因。尽管果蝇和哺乳动物神经胶质细胞之间存在明显差异,但控制终末分化的分子机制似乎保存完好。

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