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首页> 外文期刊>Neuron glia biology >Myelin structure and composition of myelinated tissue in the African lungfish
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Myelin structure and composition of myelinated tissue in the African lungfish

机译：非洲肺鱼的髓磷脂结构和有髓组织的组成

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To analyze myelin structure and the composition of myelinated tissue in the African lungfish (Protopterus dolloi), we used a combination of ultrastructural and biochemical techniques. Electron microscopy showed typical multilamellar myelin: CNS sheaths abutted one another, and PNS sheaths were separated by endoneurial collagen. The radial component, prominent in CNS myelin of higher vertebrates, was suggested by the pattern of staining but was poorly organized. The lipid and myelin protein compositions of lungfish tissues more closely resembled those of teleost than those of higher vertebrates (frog, mouse). Of particular note, for example, lungfish glycolipids lacked hydroxy fatty acids. Native myelin periodicities from unfixed nerves were in the range of those for higher vertebrates rather than for teleost fish. Lungfish PNS myelin had wider intermembrane spaces compared with other vertebrates, and lungfish CNS myelin had spaces that were closer in value to those in mammalian than to amphibian or teleost myelins. The membrane lipid bilayer was narrower in lungfish PNS myelin compared to other vertebrates, whereas in the CNS myelin the bilayer was in the typical range. Lungfish PNS myelin showed typical compaction and swelling responses to incubation in acidic or alkaline hypotonic saline. The CNS myelin, by contrast, did not compact in acidic saline but did swell in the alkaline solution. This lability was more similar to that for the higher vertebrates than for teleost.
机译：为了分析非洲肺鱼（Protopterus dolloi）的髓磷脂结构和髓鞘组织组成，我们结合使用了超微结构和生化技术。电子显微镜检查显示典型的多层髓鞘蛋白：CNS鞘相互邻接，PNS鞘被神经内膜胶原分开。径向模式在高等脊椎动物的中枢神经系统髓磷脂中突出，由染色模式提示，但组织较差。与高等脊椎动物（青蛙，小鼠）相比，肺鱼组织的脂质和髓磷脂蛋白质组成与硬骨鱼类更相似。特别值得注意的是，例如，肺鱼糖脂缺乏羟基脂肪酸。来自不固定神经的天然髓磷脂周期处于高等脊椎动物而不是硬骨鱼类的周期中。与其他脊椎动物相比，肺鱼PNS髓磷脂的膜间空间更宽，而肺鱼CNS髓磷脂的空间比两栖动物或硬骨鱼髓肉更接近哺乳动物。与其他脊椎动物相比，肺鱼PNS髓磷脂的膜脂双层更窄，而中枢神经系统髓磷脂的双层膜脂双层在典型范围内。肺鱼PNS髓磷脂对在酸性或碱性低渗盐水中孵育具有典型的紧实和肿胀反应。相比之下，CNS髓磷脂在酸性盐水中不致密，但在碱性溶液中却溶胀。这种不稳定性与高等脊椎动物比硬骨鱼类更相似。

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