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首页> 外文期刊>Neurocase: case studies in neuropsychology, neuropsychiatry, and behavioural neurology >A clinical, neurolinguistic, and radiological study of a Chinese follow-up case with primary progressive aphasia
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A clinical, neurolinguistic, and radiological study of a Chinese follow-up case with primary progressive aphasia

机译：一项中国原发性进行性失语症随访病例的临床，神经语言学和放射学研究

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Primary progressive aphasia (PPA) is a progressive neurodegenerative disorder characterized by the deterioration of language functions. The Han language bears some unique features from the Latin languages; however, the features of PPA in the Han language-speaking population are not well understood. In this study, we performed a 3-year follow-up on a Han language-speaking PPA patient with corresponding changes in magnetic resonance imaging (MRI). During the early stage, linguistic analysis revealed several symptoms including difficulty with auditory comprehension, right-left disorientation, reading disorders, and agraphia, specifically the execution of serial oral instructions. This Chinese PPA patient presented with a reading disorder, but his word comprehension ability remained intact. There are two different possible modalities of incorrect writing in this case. The patient also presented with noun-verb double dissociation. The early-stage MRI showed atrophy of the left frontal lobe, which was most severe in the inferior frontal gyrus. Three years later, the patient was found to have progressive atrophy in the parietal, frontal, and temporal lobes, among which the frontal lobe remained the most severely affected region. The brain imaging of the Chinese-speaking PPA patient showed changes similar to those of a Latin language-speaking PPA patient. The prominent change was asymmetrical atrophy in the frontal and temporal lobes. This is the first report of noun-verb double dissociation existing in a Chinese-language speaking PPA patient. The dissociation may be related to an impaired function of the inferior frontal gyrus, which is likely associated with verb-naming in Chinese-speaking people. Several unique features were observed in this case, including impairment in writing ability.
机译：原发性进行性失语症（PPA）是一种进行性神经退行性疾病，其特征是语言功能下降。汉语具有拉丁语的一些独特特征。但是，对讲汉语言的人来说，PPA的特征还不是很清楚。在这项研究中，我们对讲汉语的PPA患者进行了为期3年的随访，并在磁共振成像（MRI）中进行了相应的更改。在早期阶段，语言分析显示了几种症状，包括听觉理解困难，左右迷失方向，阅读障碍和失语症，特别是执行了一系列口头指示。这位中国PPA患者出现阅读障碍，但他的单词理解能力仍然完好无损。在这种情况下，存在两种不同的错误书写方式。患者还出现名词-动词双重解离。早期MRI显示左额叶萎缩，在额下回中最为严重。三年后，发现该患者的顶叶，额叶和颞叶萎缩，其中额叶仍是受影响最严重的区域。讲华语的PPA患者的大脑成像显示出与讲拉丁语的PPA患者相似的变化。突出的变化是额叶和颞叶的不对称萎缩。这是华语PPA患者中名词-动词双离解的首次报道。分离可能与额下回功能受损有关，这可能与说汉语的人的动词命名有关。在这种情况下，观察到一些独特的功能，包括书写能力受损。

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