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Authors response to scientific correspondence

机译：作者对科学通信的回应

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In this scientific correspondence, Dr Jellinger who is an expert in the field and has published extensively on multiple system atrophy (MSA), adds three additional points to our recent review [1] on the neuropathology, patho-physiology and genetics of MSA.The first point relates to neuropathological grading in MSA, with Dr Jellinger highlighting a study in which both the severity of striatonigral degeneration (SND) and olivopontocerebellar atrophy (OPCA) pathology was graded and correlated with clinical variables [2], This study by Jellinger et al. [2], was very similar to a study described, in our review, by Ozawa et al. [3], with the former analysing 42 and the latter analysing 100 pathologically confirmed MSA cases. Both studies were in agreement, that the majority of MSA cases (approximately 50%) had equivalent SND and OPCA grades (e.g. SND II/OPCA If). Along with these 'mixed' cases, the grading strategy proposed by Ozawa et al. [3], allowed for the identification of cases with OPCA- or SND-predominant pathology. In contrast, no MSA case had an OPCA grade that was higher than its SND grade when using the scheme described by Jellinger et al. [2], although numerous cases had an SND grade that was greater than their OPCA grade.
机译：在这一科学通讯中，本领域的专家杰林格（Jellinger）博士在多系统萎缩症（MSA）方面发表了广泛的著作，为我们最近关于MSA的神经病理学，病理生理学和遗传学的综述[1]增加了三点。第一点与MSA的神经病理学分级有关，Jellinger博士着重强调了一项研究，其中对纹状体黑质变性（SND）和少脑小脑萎缩（OPCA）病理的严重程度进行分级并与临床变量相关[2]，该研究由Jellinger等进行。 [2]与Ozawa等人在我们的评论中描述的一项研究非常相似。 [3]，前者分析42例，后者分析100例经病理证实的MSA病例。两项研究都一致，大多数MSA病例（约50％）具有相同的SND和OPCA等级（例如SND II / OPCA If）。与这些“混合”案例一起，Ozawa等人提出了分级策略。 [3]，允许以OPCA或SND为主的病理学鉴别病例。相反，当使用Jellinger等人描述的方案时，没有MSA病例的OPCA等级高于其SND等级。 [2]，尽管许多病例的SND评分均高于OPCA评分。

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