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首页> 外文期刊>Neuropathology and applied neurobiology >Neuroinflammation in ageing and in neurodegenerative disease
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Neuroinflammation in ageing and in neurodegenerative disease

机译：衰老和神经退行性疾病中的神经炎症

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To determine the prevalence and risk factors for (i) overweight/obesity and (ii) weight gain six months after transplantation and to study the effect of weight excess on graft function and survival. We performed a retrospective study of kidney transplanted children. Endpoints: (i) prevalence of overweight/obesity at sixth month, (ii) gaining 1.0 BMI SDS from one to six months. To study the effects of weight excess, graft function and survival at 36 months were the endpoints. The study included 197 individuals. At sixth month, 57/197 (29%) presented overweight/obesity, and the factors associated to this outcome were: (i) age at transplantation (OR = 3.04) and (ii) overweight/obesity in the first month (OR = 22.16). Groups presented no difference on graft function and survival at 36 months. From one to six months, 90/197 (46%) patients gained >1.0 BMI SDS. This outcome was associated with (i) female sex (OR = 2.50), (ii) steroids' pulses (OR = 2.98), (iii) steroids exposure (OR = 1.04), and (iv) living donor (OR = 2.69). The group that gained BMI presented a lower 36 months graft survival (86% vs. 98%, p < 0.001). Weight excess and gain after transplantation are frequent, particularly in younger female recipients and in those receiving high steroids exposure. The lower graft survival in patients with rapid weight gain deserves investigation.
机译：确定（i）超重/肥胖和（ii）移植后六个月体重增加的患病率和危险因素，并研究体重超标对移植物功能和存活的影响。我们进行了肾脏移植儿童的回顾性研究。终点：（i）第六个月超重/肥胖的患病率，（ii）一到六个月获得1.0 BMI SDS。为了研究体重过剩的影响，移植功能和36个月生存率是终点。该研究包括197个人。在第六个月，有57/197（29％）的患者出现超重/肥胖，并且与该结果相关的因素包括：（i）移植时的年龄（OR = 3.04）和（ii）第一个月的超重/肥胖（OR = 22.16）。各组在36个月时的移植物功能和存活率无差异。从1到6个月，有90/197（46％）的患者获得了> 1.0的BMI SDS。该结果与（i）女性（OR = 2.50），（ii）类固醇的脉搏（OR = 2.98），（iii）类固醇暴露（OR = 1.04）和（iv）活体供体（OR = 2.69）相关。获得BMI的组的移植物生存期较低（86％比98％，p <0.001）。移植后体重经常增加和增加，特别是在年轻的女性接受者和接受高类固醇暴露的患者中。体重快速增加的患者移植物存活率较低，值得研究。

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