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首页> 外文期刊>Neuropathology and applied neurobiology >The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion
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The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion

机译：脑儿茶酚-O-甲基转移酶（COMT）和蛋氨酸亚砜还原酶的酶活性以COMT Val / Met等位基因依赖的方式相关

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AimsThe enzyme catechol-O-methyltransferase (COMT) plays a primary role in the metabolism of catecholamine neurotransmitters and is implicated in the modulation of cognitive and emotional responses. The best characterized single nucleotide polymorphism (SNP) of the COMT gene consists of a valine (Val)-to-methionine (Met) substitution at codon 108/158. The Met-containing variant confers a marked reduction in COMT catalytic activity. We recently showed that the activity of recombinant COMT is positively regulated by the enzyme Met sulphoxide reductase (MSR), which counters the oxidation of Met residues of proteins. The current study was designed to assess whether brain COMT activity may be correlated to MSR in an allele-dependent fashion.
机译：目的儿茶酚-O-甲基转移酶（COMT）在儿茶酚胺神经递质的代谢中起主要作用，并参与认知和情绪反应的调节。 COMT基因最有特色的单核苷酸多态性（SNP）由密码子108/158处的缬氨酸（Val）到蛋氨酸（Met）取代组成。含Met的变体可显着降低COMT催化活性。我们最近发现重组COMT的活性受到Met亚砜还原酶（MSR）的正调控，该酶可抵抗蛋白质Met残基的氧化。当前的研究旨在评估大脑COMT活性是否可能以等位基因依赖的方式与MSR相关。

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