...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuromuscular disorders: NMD >Long-term effectiveness of acetazolamide on permanent weakness in hyperkalemic periodic paralysis
【24h】

Long-term effectiveness of acetazolamide on permanent weakness in hyperkalemic periodic paralysis

机译：乙酰唑胺对高钾性周期性麻痹永久性衰弱的长期疗效

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acetazolamide is commonly used as an empirical treatment for inherited periodic paralyses although some patients may develop deleterious effects. We report a 65. year-old man with hyperkalemic periodic paralysis and late-onset permanent weakness in association with the common T704M mutation in α-subunit, skeletal muscle voltage-gated sodium channel gene. He rapidly recovered from weakness after acetazolamide treatment. Magnetic resonance imaging of thighs comparing pre- and post-treatment revealed a significant increase in muscle bulk. The patient has been without any type of weakness for over 6. years. This data show the remarkable benefit of acetazolamide on permanent weakness of hyperkalemic periodic paralysis in association with the T704M mutation.
机译：乙酰唑胺通常用作遗传性周期性麻痹的经验疗法，尽管有些患者可能会产生有害作用。我们报道了一名65岁的男子，患有高钾血症性周期性麻痹和迟发性永久性虚弱，并伴有α亚基，骨骼肌电压门控性钠通道基因的常见T704M突变。乙酰唑胺治疗后，他迅速从无力中恢复过来。大腿的磁共振成像比较了治疗前后，发现肌肉体积明显增加。该患者已超过6年没有任何类型的虚弱。该数据表明乙酰唑胺对高钾血症周期性麻痹与T704M突变相关的永久性弱点具有显着的益处。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号